Intravenous patient-controlled remifentanil versus paracetamol in post-operative pain management in patients undergoing coronary artery bypass graft surgery

Anesthesiology and Pain Medicine
Alireza Jahangiri FardMaziar Mahjoubifard

Abstract

Pain management after cardiac surgery has been based on parenteral long-acting opioids such as morphine. The other alternatives are paracetamol and remifentanil. In this prospective, double-blind, randomized study, we compared the efficacy of intravenous patient-controlled analgesia (IV-PCA) paracetamol and remifentanil for post cardiac surgery pain relief. One-hundred patients scheduled for elective coronary artery bypass grafting from May to October 2011, were randomized into two groups after the surgery. For the first group (group R, n = 50, with mean age of 58.16 ± 11.80), the IV-PCA protocol was remifentanil infusion 100 μg/h; bolus of 25 μg and lockout time of 15 minutes. In the second group (group P, n = 50, with mean age of 53.8 ± 15.08), patients received paracetamol 15 mg/kg as a bolus at the end of surgery and then IV-PCA protocol was 100 μg/h, bolus of 25 μg; and lockout time of 15 minutes. Pain was assessed with visual analog scale score (VAS) in the first 24 hours after surgery for seven times. The trend of pain scores did not have any significantly difference between group R and group P except for hour 8 and hour 18 after surgery that VAS was significantly lower in group P than group R (P = 0.031, P = 0.023, resp...Continue Reading

References

Jun 16, 2005·Acta Anaesthesiologica Scandinavica·K KrishnanA Mallick
Sep 1, 2005·Journal of Cardiothoracic and Vascular Anesthesia·Pia Holmér PetterssonAnders Owall
Sep 22, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Burkhard HinzKay Brune
Oct 7, 2008·Journal of Cardiothoracic and Vascular Anesthesia·Sevim BaltaliGulnaz Arslan
Dec 7, 2013·Advanced Pharmaceutical Bulletin·Mohammadreza SattariSimin Ozar Mashayekhi

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