PMID: 3773158Nov 14, 1986Paper

Intravenous penicillin desensitization and treatment during pregnancy

JAMA : the Journal of the American Medical Association
P R ZiayaA B Halsey

Abstract

Untreated syphilis during pregnancy may result in stillbirth in one fourth of cases, while in infants who survive, there may be serious immediate and delayed manifestations. Penicillin is the drug of choice for treating both mother and fetus. We describe a woman with an allergy against both major and minor determinants of penicillin in whom syphilis was diagnosed on routine obstetric screening. Her obstetric history included one vaginal delivery at term and four subsequent spontaneous abortions at 12 to 16 weeks. The patient underwent desensitization utilizing graduated intravenous doses of penicillin followed by treatment with a constant infusion for eight days. She experienced no serious allergic reactions requiring alteration of therapy. We conclude that antibiotic desensitization may be a safe alternative during pregnancy if performed with careful monitoring. In this case, it allowed use of penicillin rather than less desirable alternatives.

Citations

Apr 30, 1988·British Medical Journal·S T Holgate
Jul 10, 2004·Immunology and Allergy Clinics of North America·Roland Solensky
Jul 10, 2004·Immunology and Allergy Clinics of North America·Arveen K Thethi, R G Van Dellen
Jun 1, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Shan Shan WuDevi Jhaveri
Nov 1, 2001·The Cochrane Database of Systematic Reviews·G J Walker
Jul 26, 2005·Sexually Transmitted Diseases·Pingyu ZhouKanghuang Liao
Apr 29, 2014·Hospital Practice·Hugh Adler, John S Lambert

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