Intravenous peramivir inhibits viral replication, and leads to bacterial clearance and prevention of mortality during murine bacterial co-infection caused by influenza A(H1N1)pdm09 virus and Streptococcus pneumoniae

Antiviral Research
Motoyasu OnishiAkihiko Sato

Abstract

Influenza virus infection increases susceptibility to bacterial infection and mortality in humans. Although the efficacy of approved intravenous peramivir, a neuraminidase (NA) inhibitor, against influenza virus infection has been reported, its efficacy against bacterial co-infection, which occurs during the period of viral shedding, was not fully investigated. To further understand the significance of treatment with peramivir, we assessed the efficacy of peramivir against a bacterial co-infection model in mice caused by clinically isolated influenza A(H1N1)pdm09 virus and Streptococcus pneumoniae. Mice were infected with influenza A(H1N1)pdm09. Peramivir was intravenously administered after the viral infection. At 2days post viral infection, the mice were infected with S. pneumoniae. Peramivir efficacy was measured by the survival rates and viral titers, bacterial titers, or proinflammatory cytokine concentrations in lung homogenates. Peramivir treatment reduced the mortality of mice infected with influenza virus and S. pneumoniae. The survival rate in the peramivir-treated group was significantly higher than that in the oseltamivir-treated group. Viral titers and proinflammatory cytokine responses in the peramivir-treated gro...Continue Reading

References

Feb 27, 2001·The Pediatric Infectious Disease Journal·R J WhitleyP Ward
Jul 10, 2004·The Journal of Infectious Diseases·Jonathan A McCullers
Jul 1, 2009·Infection and Immunity·Dane ParkerAlice Prince
Nov 4, 2009·The New England Journal of Medicine·Debra Birnkrant, Edward Cox
Aug 18, 2010·Antimicrobial Agents and Chemotherapy·Shigeru KohnoUNKNOWN S-021812 Clinical Study Group
Mar 5, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Chad M CoxLyn Finelli
Jun 17, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Miguel A Hernán, Marc Lipsitch
Jan 17, 2013·JAMA : the Journal of the American Medical Association·Daniel S Chertow, Matthew J Memoli
Sep 27, 2013·Influenza and Other Respiratory Viruses·Carol JosephNahoko Shindo

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Citations

Apr 12, 2016·Frontiers in Microbiology·Malak M AlameHassan Zaraket
Oct 27, 2018·Expert Opinion on Drug Discovery·Edin J MifsudAeron C Hurt
Jun 22, 2017·The Journal of Infectious Diseases·Angela R Branche, Ann R Falsey

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