Intravenous perfluoropropane-exposed sonicated dextrose albumin produces myocardial ultrasound contrast that correlates with coronary blood flow
Abstract
If microbubble gas blood solubility and diffusivity are reduced, the persistence (and hence ultrasound reflectivity) of the microbubble in blood is prolonged. Recently we have sonicated a multifold dilution of human albumin with 5% dextrose while exposed to gases of low blood solubility and diffusivity and produced microbubbles that consistently opacify the myocardium after intravenous injection. The objective of this study was to test the hypothesis that a gas with very low diffusivity, perfluoropropane, when introduced into dextrose albumin during sonication, would produce visually evident myocardial ultrasound contrast after intravenous injection compared to sonicating with gases that have more rapid diffusivity. Second, we sought to determine whether the degree of contrast (peak myocardial videointensity) achieved with this agent would correlate with coronary blood flow. In eight open-chest dogs, intravenous injections of dextrose albumin sonicated with either room air, sulfur hexafluoride, or perfluoropropane (PESDA) were given under baseline conditions. PESDA injections were repeated when coronary flow was increased during low-dose dobutamine infusion. Left anterior descending coronary blood flow was monitored with transi...Continue Reading
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