Intravenous perfluoropropane-exposed sonicated dextrose albumin produces myocardial ultrasound contrast that correlates with coronary blood flow

Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography
T R PorterK Kilzer

Abstract

If microbubble gas blood solubility and diffusivity are reduced, the persistence (and hence ultrasound reflectivity) of the microbubble in blood is prolonged. Recently we have sonicated a multifold dilution of human albumin with 5% dextrose while exposed to gases of low blood solubility and diffusivity and produced microbubbles that consistently opacify the myocardium after intravenous injection. The objective of this study was to test the hypothesis that a gas with very low diffusivity, perfluoropropane, when introduced into dextrose albumin during sonication, would produce visually evident myocardial ultrasound contrast after intravenous injection compared to sonicating with gases that have more rapid diffusivity. Second, we sought to determine whether the degree of contrast (peak myocardial videointensity) achieved with this agent would correlate with coronary blood flow. In eight open-chest dogs, intravenous injections of dextrose albumin sonicated with either room air, sulfur hexafluoride, or perfluoropropane (PESDA) were given under baseline conditions. PESDA injections were repeated when coronary flow was increased during low-dose dobutamine infusion. Left anterior descending coronary blood flow was monitored with transi...Continue Reading

Citations

Nov 19, 2011·Amino Acids·Sonia MelinoMuthupandian Ashokkumar
Jun 12, 2009·Medical & Biological Engineering & Computing·Alexander L Klibanov
Apr 24, 2001·Ultrasound in Medicine & Biology·T R PorterS Radio
Jul 22, 1999·Ultrasound in Medicine & Biology·A L Strauss, K D Beller
Jul 1, 1997·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·P J ColonJ Cheirif
Dec 26, 2001·Investigative Radiology·G J SchafflerM M Uggowitzer
Jul 29, 2000·Australian and New Zealand Journal of Medicine·U Premawardhana, D S Celermajer
Jul 21, 2001·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·M KapsA Broillet
Jul 7, 2012·Ultrasound in Medicine & Biology·Robert P GarvinDaniel R Anderson
Jan 1, 1997·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·T OtaP K Smith
Oct 15, 2005·Ultrasound in Medicine & Biology·John C ChappellRichard J Price
Dec 5, 2002·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Edda B BahlmannMarielle Scherrer-Crosbie
Jan 5, 2013·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Telli FaezNico de Jong
Jul 1, 1996·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·T R PorterK Kilzer
Feb 6, 2020·Soft Matter·Aaqib H Khan, Sameer V Dalvi
Jul 17, 1998·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·G SeidelM Kaps
Apr 29, 1998·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·G SeidelM Kaps
Jul 16, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Aaqib H KhanSameer V Dalvi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Related Papers

Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography
N K GandhokS B Feinstein
Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography
J G WarnerD W Kitzman
Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
J R Lindner, S Kaul
Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography
D S BachJ Cheirif
© 2021 Meta ULC. All rights reserved