PMID: 6981172Mar 1, 1982Paper

Intravenous pharmacokinetics and in vitro bactericidal activity of trimethoprim-sulfamethoxazole

Reviews of Infectious Diseases
J SpicehandlerJ J Rahal

Abstract

Trimethoprim-sulfamethoxazole (240 mg of trimethoprim plus 1,200 mg of sulfamethoxazole) was administered intravenously in a volume of 200 ml to 7 volunteers every 12 hr for 4 days. The mean peak levels of TMP and SMZ in plasma were 3.22 and 100 micrograms/ml, respectively, on day 1 and 5.91 and 178 micrograms/ml, respectively, on day 4, when a steady state was achieved. Tests of in vitro susceptibility indicated that these concentrations are bactericidal for a large proportion of enteric gram-negative bacilli.

Citations

Jun 1, 1984·European Journal of Clinical Microbiology·F R Sattler, J S Remington
Jun 10, 2014·Annals of Intensive Care·Glen R Brown
Sep 1, 1989·DICP : the Annals of Pharmacotherapy·C M Paap, M C Nahata

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