Intravenous proton pump inhibition utilization and prescribing patterns escalation: a comparison between early and current trends in use

Gastrointestinal Endoscopy
Joanna K LawRobert Enns

Abstract

Approved indications of intravenous (i.v.) proton pump inhibition (PPI) are limited to treatment of reflux esophagitis in patients unable to tolerate oral medications and for patients with pathologic hypersecretory states. i.v. PPIs are commonly used after endoscopic evaluation of patients with high-risk endoscopic stigmata (HRES) of nonvariceal upper GI bleeding (NVUGIB). There appears to have been an expansion of indications of this drug at many centers. All consecutive patients receiving i.v. PPI (pantoprazole) between 2 study periods, (1) when pantoprazole was restricted to the gastroenterology service and (2) when it was unrestricted, were reviewed. Tertiary care university hospital. All receiving i.v. PPI. i.v. PPI utilization. Percentage of patients receiving i.v. PPI for indications other than bleeding during 2 time periods. In the early period, 217 patients (67.30% male) received i.v. PPI on 218 occasions compared with 516 patients (65.31% male, P= .61) in the later period on 613 occasions. In the early group, 93.12% of 217 patients received i.v. PPI for NVUGIB compared with 56.12% of 516 patients (P< .0001) with 18% of patients receiving i.v. PPI for nothing by mouth status and 13% for abdominal pain in the later grou...Continue Reading

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Citations

Feb 25, 2010·World Journal of Gastroenterology : WJG·Soumana C NasserHani I Dimassi
May 13, 2011·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·David Baribeault, Michael Auerbach
Jul 26, 2014·Expert Review of Pharmacoeconomics & Outcomes Research·Jayashri SankaranarayananKeith M Olsen
Jan 1, 2014·International Scholarly Research Notices·Biswa Mohan PadhyYogendra Kumar Gupta

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