Intravenous pulse methylprednisolone therapy for acute treatment of serpiginous choroiditis

Ocular Immunology and Inflammation
Nikos N MarkomichelakisTasos Kouris

Abstract

To evaluate the safety and efficacy of high-dose intravenous steroid therapy (HDIST) for the acute treatment of vision-threatening serpiginous choroiditis. Retrospective review of the records of five patients with serpiginous choroiditis who were treated with HDIST (1 g methylprednisolone for three days) in addition to their standard immunosuppressive treatment. The visual acuities and improvement of ocular signs after HDIST were evaluated. Twelve episodes of macula-threatening choroiditis in five patients with serpiginous choroiditis were treated during a seven-year period. All patients responded to HDIST with evidence of a decrease in intraocular inflammation immediately after and complete restoration of visual acuity within 10 days of commencing treatment. In one patient, medical intervention was required because of gastric distress. During the follow-up, three out of five patients experienced new attacks and two patients developed subretinal neovascularization. HDIST is effective in controlling severe vision-threatening serpiginous choroiditis and in improving visual function in a short period of time. However, the effect of this treatment in long-term disease control is uncertain.

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Citations

Dec 24, 2009·Indian Journal of Ophthalmology·S SudharshanJyotirmay Biswas
Oct 23, 2013·Indian Journal of Ophthalmology·Kumar SaurabhJyotirmay Biswas
Mar 14, 2013·Ocular Immunology and Inflammation·Víctor LlorençAlfredo Adán
Apr 2, 2013·Survey of Ophthalmology·Hossein Nazari Khanamiri, Narsing A Rao
Mar 14, 2012·Ocular Immunology and Inflammation·Leon D CharkoudianJohn H Kempen
Oct 15, 2013·Seminars in Ophthalmology·Divya BalakrishnanJay Chhablani
Sep 1, 2012·Asia-Pacific Journal of Ophthalmology·Radha AnnamalaiJyotirmay Biswas
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Mar 24, 2017·International Journal of Retina and Vitreous·Meisha L RavenJustin L Gottlieb

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