Intravenous recombinant tissue-type plasminogen activator in patients with unstable angina pectoris. Results of a placebo-controlled, randomized trial

Circulation
D O WilliamsN S Kleiman

Abstract

Because thrombus formation may contribute to coronary obstruction in patients with unstable angina pectoris, we performed a pilot investigation to determine whether thrombolytic therapy can relieve coronary narrowing in this acute ischemic syndrome. Sixty-seven patients with rest angina and angiographic evidence of coronary stenosis were randomly assigned to receive either low-dose intravenous recombinant tissue-type plasminogen activator (rt-PA) (0.75 mg/kg over 1 hour), high-dose intravenous rt-PA (0.75 mg/kg over 1 hour; total dose, 100 mg over 6 hours), or intravenous placebo followed by repeat coronary angiography at 24-48 hours to assess change in the severity of coronary narrowing. Each patient also received oral aspirin and intravenous heparin. Mean values of coronary stenosis severity (percent of diameter reduction) declined to a similar extent in each group: placebo, 75 +/- 14% to 72 +/- 14% (p = 0.07); low-dose rt-PA, 75 +/- 16% to 71 +/- 18% (p = 0.03), and high-dose rt-PA, 82 +/- 11% to 77 +/- 17% (p = 0.18), with only the low-dose rt-PA group achieving statistical significance. Resolution of intracoronary filling defects, increase in antegrade flow grade, or both also occurred equally among the three groups. There...Continue Reading

References

Feb 1, 1989·Journal of the American College of Cardiology·J M NicklasB Pitt
Oct 27, 1988·The New England Journal of Medicine·P ThérouxP deGuise
Aug 1, 1988·Journal of the American College of Cardiology·C de ZwaanH J Wellens
Nov 28, 1985·The New England Journal of Medicine·J A CairnsM G Myers
Mar 1, 1985·Journal of the American College of Cardiology·J A AmbroseV Fuster
Aug 1, 1985·Journal of the American College of Cardiology·D R BresnahanH C Smith
Sep 1, 1985·The American Journal of Cardiology·G CaponeS G Meister
Apr 4, 1985·The New England Journal of Medicine·UNKNOWN TIMI Study Group
Apr 12, 1973·The New England Journal of Medicine·P B OlivaR G Pluss
Jul 1, 1983·The American Journal of Cardiology·J B MandelkornS G Meister

❮ Previous
Next ❯

Citations

Sep 1, 1993·Clinical Cardiology·S BorzakM Lesch
May 1, 1992·Journal of Clinical Pharmacology·L M PrisantM J Frank
Mar 1, 1993·Journal of the American College of Cardiology·R L WilenskyJ A Zeller
Nov 1, 1994·Journal of the American College of Cardiology·P T Vaitkus, W K Laskey
Nov 15, 1994·Journal of the American College of Cardiology·F W BärH J Wellens
Sep 20, 1997·The American Journal of Cardiology·F CreaA Maseri
Mar 1, 1996·Progress in Cardiovascular Diseases·N M Keller, F Feit
Feb 6, 1999·Journal of the American College of Cardiology·S M ZaacksL W Klein
Jan 30, 1992·The New England Journal of Medicine·K MizunoJ A Ambrose
Dec 5, 1997·Journal of Cardiovascular Pharmacology·X H Xiao, L K Holley
Nov 4, 1995·Journal of Interventional Cardiology·F Crea, M L Finocchiaro
Jun 11, 2002·Journal of Interventional Cardiology·P A McCulloughC L Grines
Jul 1, 2006·Clinical Medicine & Research·Shereif H Rezkalla, David R Holmes
Nov 28, 2013·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Fabio AngeliClaudio Cavallini
Sep 3, 1991·The American Journal of Cardiology·A Maseri, F Crea
Sep 3, 1991·The American Journal of Cardiology·J A Ambrose, D H Israel
Sep 3, 1991·The American Journal of Cardiology·M L BrochierG Pacouret
Sep 3, 1991·The American Journal of Cardiology·C BrunelliS Caponnetto
Jan 15, 1992·The American Journal of Cardiology·H ChaudharyH Ikram
Mar 1, 1993·Current Problems in Cardiology·P Théroux, R M Lidón
Sep 1, 1993·International Journal of Cardiology·D H Israel, J A Ambrose
Jan 1, 1993·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·K MizunoM Kikuchi
Jun 29, 1999·Cardiology Clinics·P A McCullough, W W O'Neill
Nov 4, 1991·The American Journal of Cardiology·J H ChesebroV Fuster
Nov 4, 1991·The American Journal of Cardiology·D WatersP Théroux
Nov 4, 1991·The American Journal of Cardiology·S SenH Schieffer
Sep 3, 1991·The American Journal of Cardiology·D ScrutinioP Rizzon
Feb 1, 1996·Italian Journal of Neurological Sciences·L CandeliseA P Maggioni

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.