Intravenous sulfamethoxazole-trimethoprim: pharmacokinetics, therapeutic indications, and adverse reactions

Pharmacotherapy
R GleckmanD W Joubert

Abstract

Biogenesis of tetrahydrofolate cofactors essential for bacterial growth and survival is blocked by sulfamethoxazole-trimethoprim. An intravenous form of the antimicrobial combination has recently been approved for the treatment of acute, symptomatic, bacterial pyelonephritis, recurrent urinary tract infections, shigellosis, and Pneumocystis carinii pneumonia. Intravenous sulfamethoxazole-trimethoprim has emerged as an invaluable agent for the management of selected infections, including bacterial meningitis and Salmonella bacteremia, where limited therapeutic alternatives exist. In addition, co-administration of intravenous sulfamethoxazole-trimethoprim with a carboxypenicillin provides an empiric treatment for the infected granulocytopenic patient that compares favorably with standard combinations. Adverse events unique to the intravenous form of the drug consist of phlebitis and fluid imbalances. Fluid overload results from the relatively large volumes of 5% dextrose solution required as diluent.

References

Feb 1, 1977·Archives of Disease in Childhood·P J Helms
Dec 1, 1977·British Journal of Obstetrics and Gynaecology·D D MathewsJ Cooper
Aug 12, 1978·British Medical Journal·C MorranC S McArdle
Sep 1, 1979·British Journal of Obstetrics and Gynaecology·D D MathewsJ Cooper
Mar 1, 1979·Antimicrobial Agents and Chemotherapy·W E GroseT L Loo
Nov 1, 1979·The Journal of Antimicrobial Chemotherapy·A Svedhem, S Iwarson
Jul 15, 1978·British Medical Journal·N Buchanan
Jul 1, 1978·The Medical Journal of Australia·B C StratfordS Dixson
Sep 23, 1976·The New England Journal of Medicine·W K Lau, L S Young
Jan 1, 1975·Acta paediatrica Scandinavica·K G Sabel, A Brandberg
Feb 1, 1975·Postgraduate Medical Journal·G C Hanson, R L Woods
Jan 1, 1975·Scandinavian Journal of Infectious Diseases·M Eriksson, P Olcén
Jan 1, 1976·Annals of Internal Medicine·Z FaridW Yassin
Oct 1, 1973·Journal of Clinical Pathology·S P Lapage, R J Owen
Jun 1, 1980·Annals of Internal Medicine·D J WinstonL S Young
Jun 1, 1981·The American Journal of Medicine·F R Sattler, J S Remington
Jun 1, 1981·Annals of Internal Medicine·N L Kobrinsky, N K Ramsay
Feb 1, 1980·The British Journal of Surgery·A F HigginsM L Hole
Jan 1, 1980·The American Journal of the Medical Sciences·W E Grose, G P Bodey
Feb 1, 1980·Antimicrobial Agents and Chemotherapy·D J Morgan, K Raymond

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