Intravenous thrombolysis followed by intra-arterial thrombolysis and mechanical thrombectomy for the treatment of pediatric ischemic stroke

Journal of the Neurological Sciences
Georgios TsivgoulisAndrei V Alexandrov

Abstract

Experience with systemic or selective local administration of thrombolytic agents in pediatric ischemic stroke is limited to sporadic case reports, since patients of age less than 18 years were systematically excluded from randomised controlled trials. We report a case of childhood IS attributable to the terminal internal carotid artery occlusion that was treated successfully with mechanical thrombectomy which followed unsuccessful attempts to recanalize the artery with intravenous and intra-arterial thrombolytics. Combined systemic and intra-arterial thrombolysis followed by mechanical thrombectomy can be feasible and may be considered as means of achieving reperfusion in pediatric ischemic stroke patients with persisting arterial occlusion.

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Citations

Nov 3, 2009·Current Opinion in Pediatrics·Nomazulu Dlamini, Fenella J Kirkham
May 24, 2011·Stroke Research and Treatment·Giuseppe LanniMassimo Gallucci
Apr 2, 2011·Expert Opinion on Emerging Drugs·Joanne Ng, Vijeya Ganesan
Oct 22, 2013·Pediatric Neurology·Sophie DubedoutEmmanuel Cheuret
Jan 4, 2012·World Neurosurgery·Iris Quasar Grunwald, Anna Luisa Kühn
Nov 26, 2010·Pediatric Neurology·Marcia V FelkerMeredith R Golomb
Nov 26, 2013·Journal of Child Neurology·Susana Sainz de la MazaJaime Masjuan
Nov 27, 2014·Neurointervention·David A Stidd, Demetrius K Lopes
Dec 15, 2017·Frontiers in Neurology·Ashish KulhariCiro Ramos-Estebanez
Mar 3, 2020·Stroke; a Journal of Cerebral Circulation·Aristeidis H Katsanos
Mar 16, 2021·Stroke; a Journal of Cerebral Circulation·Megan BarryUNKNOWN Thrombolysis in Pediatric Stroke (TIPSTER) Investigators*

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