Intravenous thrombolysis for acute ischemic stroke patients presenting with mild symptoms

International Journal of Stroke : Official Journal of the International Stroke Society
Daniel StrbianHelsinki Stroke Thrombolysis Registry Group

Abstract

Thrombolysis of ischemic stroke patients presenting with mild symptoms is controversial. We aimed to describe the clinical outcome and frequency of infarcts and symptomatic intracerebral hemorrhages on follow-up imaging of such thrombolysis-treated patients. Our cohort included 1398 consecutive ischemic stroke patients treated with intravenous thrombolysis at the Helsinki University Central Hospital, years 1995-2010. We analyzed the patients according to baseline National Institutes of Health Stroke Scale: ≤2, 3-4, 5-6, and >6. In our institution, visualization of an artery occlusion or perfusion deficit is required for thrombolysis with National Institutes of Health Stroke Scale ≤ 2. We used univariate and multivariable methods to describe the cohort and study associations between the variables. Excellent three-month outcome was defined as modified Rankin Scale 0-1. Fifty-eight (4·1%) patients were treated with National Institutes of Health Stroke Scale ≤ 2, another 194 (13·6%) with 3-4 points, and 236 (16·5%) with 5-6 points. With National Institutes of Health Stroke Scale ≤ 2, 45 (78%) of the patients had excellent three-month outcome, achieved in 116 (59%) patients with National Institutes of Health Stroke Scale 3-4, in 130...Continue Reading

References

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Citations

Aug 13, 2014·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Leonard L L YeoVijay K Sharma
Jul 27, 2014·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Qiang HuangJian Wu
Feb 22, 2016·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Sigrid B SørensenDavid C Tong
Dec 30, 2014·International Journal of Stroke : Official Journal of the International Stroke Society·Amy Y X YuShelagh B Coutts
Mar 5, 2014·Acta Neurologica Scandinavica. Supplementum·N LogalloL Thomassen
May 23, 2015·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Tyler A BrownLawrence L Latour
Sep 23, 2014·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Leonard L L YeoVijay K Sharma
Jul 5, 2016·Frontiers in Neurology·Aleksandra YakhkindShadi Yaghi
Sep 14, 2016·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Gaurav GadodiaFadi Nahab
Sep 30, 2017·Stroke and Vascular Neurology·P BhogalM Aguilar Pérez
Nov 5, 2014·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Lei ShiYuming Xu

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Software Mentioned

Confidence Interval Analysis
Systat
Statistical Package for the Social Sciences ( SPSS )
SigmaPlot

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