Abstract
Thrombolysis of ischemic stroke patients presenting with mild symptoms is controversial. We aimed to describe the clinical outcome and frequency of infarcts and symptomatic intracerebral hemorrhages on follow-up imaging of such thrombolysis-treated patients. Our cohort included 1398 consecutive ischemic stroke patients treated with intravenous thrombolysis at the Helsinki University Central Hospital, years 1995-2010. We analyzed the patients according to baseline National Institutes of Health Stroke Scale: ≤2, 3-4, 5-6, and >6. In our institution, visualization of an artery occlusion or perfusion deficit is required for thrombolysis with National Institutes of Health Stroke Scale ≤ 2. We used univariate and multivariable methods to describe the cohort and study associations between the variables. Excellent three-month outcome was defined as modified Rankin Scale 0-1. Fifty-eight (4·1%) patients were treated with National Institutes of Health Stroke Scale ≤ 2, another 194 (13·6%) with 3-4 points, and 236 (16·5%) with 5-6 points. With National Institutes of Health Stroke Scale ≤ 2, 45 (78%) of the patients had excellent three-month outcome, achieved in 116 (59%) patients with National Institutes of Health Stroke Scale 3-4, in 130...Continue Reading
References
Dec 14, 1995·The New England Journal of Medicine·UNKNOWN National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group
Oct 4, 1995·JAMA : the Journal of the American Medical Association·W HackeM H Mahagne
Oct 27, 1998·Lancet·W HackeP Trouillas
Dec 29, 1998·Annals of Emergency Medicine·R E O'ConnorL Edelsohn
Apr 26, 2001·Neurology·P A BarberA M Buchan
Feb 2, 2002·Stroke; a Journal of Cerebral Circulation·Gregory W AlbersScott A Hamilton
Jan 24, 2004·Stroke; a Journal of Cerebral Circulation·Dawn KleindorferUNKNOWN Neuroscience Institute
Mar 17, 2004·Archives of Neurology·Irene L KatzanUNKNOWN Cleveland Clinic Health System Stroke Quality Improvement Team
Sep 4, 2004·Stroke; a Journal of Cerebral Circulation·Timothy John IngallTeresa J Hengy Christianson
Oct 21, 2004·JAMA : the Journal of the American Medical Association·Perttu J LindsbergMarkku Kaste
Feb 25, 2005·Neurology·D CochoJ-L Martí-Vilalta
Aug 30, 2005·Annals of Emergency Medicine·UNKNOWN National Institute of Neurological Disorders Stroke rt-PA Stroke Study Group
Oct 8, 2005·Stroke; a Journal of Cerebral Circulation·Eric E SmithLee H Schwamm
Dec 14, 2005·Neurology·Pedro Schestatsky, Paulo Dornelles Picon
Mar 25, 2006·Stroke; a Journal of Cerebral Circulation·Christian R BaumannDimitrios Georgiadis
Sep 27, 2006·Neurology·V RajajeeJ L Saver
Apr 14, 2007·Annals of Neurology·Jessica C TanMax Wintermark
Aug 4, 2007·Stroke; a Journal of Cerebral Circulation·Krassen NedeltchevHeinrich P Mattle
Dec 19, 2008·Cerebrovascular Diseases·M KöhrmannP D Schellinger
Jul 3, 2009·Cerebrovascular Diseases·Nikolai SteffenhagenShelagh B Coutts
Nov 11, 2009·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Laura J GrayUNKNOWN Virtual International Stroke Trials Archive Collaboration
Feb 20, 2010·Stroke; a Journal of Cerebral Circulation·Daniel StrbianUNKNOWN Helsinki Stroke Thrombolysis Registry Group
Jun 12, 2010·Stroke; a Journal of Cerebral Circulation·Atte MeretojaMarkku Kaste
Sep 4, 2010·Stroke; a Journal of Cerebral Circulation·Pooja KhatriJoseph P Broderick
Oct 16, 2010·Stroke; a Journal of Cerebral Circulation·Nishant K MishraUNKNOWN VISTA Collaborators
Citations
Oct 26, 2013·BMC Neurology·Zilong HaoXueli Chang
Mar 26, 2013·PloS One·Xabier UrraÁngel Chamorro
Aug 13, 2014·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Leonard L L YeoVijay K Sharma
Jul 27, 2014·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Qiang HuangJian Wu
Feb 2, 2013·Expert Review of Neurotherapeutics·Karl Matz, Michael Brainin
Feb 22, 2016·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Sigrid B SørensenDavid C Tong
Dec 30, 2014·International Journal of Stroke : Official Journal of the International Stroke Society·Amy Y X YuShelagh B Coutts
Mar 5, 2014·Acta Neurologica Scandinavica. Supplementum·N LogalloL Thomassen
May 23, 2015·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Tyler A BrownLawrence L Latour
Sep 23, 2014·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Leonard L L YeoVijay K Sharma
Jul 5, 2016·Frontiers in Neurology·Aleksandra YakhkindShadi Yaghi
Sep 14, 2016·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Gaurav GadodiaFadi Nahab
Jul 2, 2016·AJNR. American Journal of Neuroradiology·J PfaffM Möhlenbruch
Mar 31, 2018·Stroke and Vascular Neurology·Shoujiang YouChun-Feng Liu
Sep 30, 2017·Stroke and Vascular Neurology·P BhogalM Aguilar Pérez
Nov 5, 2014·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Lei ShiYuming Xu
Mar 17, 2018·BMC Neurology·Dae-Hyun KimJae-Kwan Cha