Intravenous thrombolysis for large vessel or distal occlusions presenting with mild stroke severity.

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
Georgios TsivgoulisAndrei V Alexandrov

Abstract

We investigated the effectiveness of intravenous thrombolysis (IVT) in acute ischaemic stroke (AIS) patients with large vessel or distal occlusions and mild neurological deficits, defined as National Institutes of Health Stroke Scale scores < 6 points. The primary efficacy outcome was 3-month functional independence (FI) [modified Rankin Scale (mRS) scores 0-2] that was compared between patients with and without IVT treatment. Other efficacy outcomes of interest included 3-month favorable functional outcome (mRS scores 0-1) and mRS score distribution at discharge and at 3 months. The safety outcomes comprised all-cause 3-month mortality, symptomatic intracranial hemorrhage (ICH), asymptomatic ICH and severe systemic bleeding. We evaluated 336 AIS patients with large vessel or distal occlusions and mild stroke severity (mean age 63 ± 15 years, 45% women). Patients treated with IVT (n = 162) had higher FI (85.6% vs. 74.8%, P = 0.027) with lower mRS scores at hospital discharge (P = 0.034) compared with the remaining patients. No differences were detected in any of the safety outcomes including symptomatic ICH, asymptomatic ICH, severe systemic bleeding and 3-month mortality. IVT was associated with higher likelihood of 3-month FI...Continue Reading

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Citations

Sep 23, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·N BoulenoirUNKNOWN MINOR-STROKE Collaborators
Feb 27, 2021·Frontiers in Neurology·Guillaume CharbonnierThierry Moulin
Mar 20, 2021·Therapeutic Advances in Neurological Disorders·Georgios TsivgoulisAndrei V Alexandrov
Jun 16, 2021·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Reza Bavarsad ShahripourThomas Hemmen
Jul 3, 2021·Journal of Clinical Medicine·Klearchos PsychogiosGeorgios Tsivgoulis

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