PMID: 9553597Apr 29, 1998Paper

Intravenous thrombolytic therapy for acute ischemic stroke. Weighing the risks and benefits of tissue plasminogen activator

Postgraduate Medicine
R L Koller, D C Anderson

Abstract

The use of intravenous tPA within 3 hours after acute ischemic stroke has been proved to increase the number of good outcomes. However, tPA is a toxic therapy that carries a substantial risk of intracerebral hemorrhage. To decrease the risk, tPA use must be restricted to a carefully selected patient population. Treatment must be administered in an intensive care setting and directed by physicians with expertise in diagnosing and managing stroke.

References

Dec 14, 1995·The New England Journal of Medicine·UNKNOWN National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group
Jul 18, 1996·The New England Journal of Medicine·UNKNOWN Multicenter Acute Stroke Trial--Europe Study GroupJ P Boissel

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Citations

Oct 2, 2007·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Richard M ZweiflerDebra D Alday
Oct 2, 2007·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Kazumi KimuraUNKNOWN Japan Multicenter Stroke Investigators' Collaboration (J-MUSIC)
Oct 2, 2007·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Karen C AlbrightMichael R K Jacoby
Feb 13, 2001·Survey of Ophthalmology·L D McCulloughR Wityk
Aug 19, 2003·Surgical Neurology·Der-Yang ChoHan-Chun Lee
Feb 26, 2004·Journal of Vascular Nursing : Official Publication of the Society for Peripheral Vascular Nursing·Kathleen Rich
May 29, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M J H AriesJ De Keyser
May 7, 2013·Cardiovascular Research·Till SaxerBert Müller
Oct 17, 2002·Emergency Medicine Clinics of North America·Leonard M Fleck, Oliver W Hayes
Feb 2, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Ashfaq ShuaibTao Yang
Dec 22, 1999·Neuroreport·G BrinkerK A Hossmann

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