PMID: 9546949Jan 1, 1997Paper

Intravenous thrombolytic therapy in acute stroke

Vascular Medicine
D C TongG W Albers

Abstract

The article reviews the experimental basis of thrombolytic therapy, and summarizes the results of the recent trials of thrombolysis. Five large clinical trails have evaluated intravenous thrombolytic therapy for the treatment of hyperacute (< 6 h) stroke. Three of these studies were negative, one was equivocal, and one was strongly positive. The failure of demonstrate efficacy definitively in four of these trials may be related to a number of methodological factors, including the type and dose of drug administered, the timing of drug administered, and the method of patient selection for treatment. The NINDS recombinant tissue plasminogen activator (rt-PA) study showed that thrombolytic therapy can be of substantial benefit when administered within 3 h of stroke onset using strict patient selection criteria and rt-PA is now FDA approved for treatment of acute stroke. However, the risk of clinically significant bleeding is elevated. To achieve the favorable risk/benefit ratio demonstrated in the NINDS trial, patients must be screened by experienced clinicians for contraindications to thrombolysis and the acute computerized tomography (CT) brain scan must be carefully evaluated for radiographic features that increase the risk of c...Continue Reading

References

Aug 1, 1978·Neurology·J P MohrH L Bleich
Dec 1, 1992·Stroke; a Journal of Cerebral Circulation·J M Wardlaw, C P Warlow
Mar 1, 1992·Stroke; a Journal of Cerebral Circulation·M J AlbertsC Bertels
May 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K OvergaardN H Diemer
Jun 1, 1992·Stroke; a Journal of Cerebral Circulation·L P CarterO Temeltas
Aug 1, 1992·Stroke; a Journal of Cerebral Circulation·K OvergaardN H Diemer
Jan 1, 1992·Progress in Cardiovascular Diseases·S R Levine, T G Brott
Jul 1, 1991·Stroke; a Journal of Cerebral Circulation·W M ClarkJ A Zivin
Oct 1, 1991·Stroke; a Journal of Cerebral Circulation·S H HorowitzJ Alvir
Apr 1, 1990·Stroke; a Journal of Cerebral Circulation·G J del ZoppoJ A Koziol
Dec 1, 1990·Stroke; a Journal of Cerebral Circulation·M M BednarC E Gross
Mar 1, 1989·Neurosurgery·B B ChehraziJ M Brock
May 1, 1989·Stroke; a Journal of Cerebral Circulation·Y OkadaT Omae
Sep 1, 1987·Journal of Neurosurgery·S M PapadopoulosJ C Sackellares
Nov 1, 1987·Stroke; a Journal of Cerebral Circulation·A Slivka, W Pulsinelli
Dec 1, 1988·Stroke; a Journal of Cerebral Circulation·J LodderP J van der Lugt
Mar 1, 1986·Stroke; a Journal of Cerebral Circulation·C R HornigA L Agnoli
Jul 1, 1986·Stroke; a Journal of Cerebral Circulation·G J Del ZoppoL A Harker
Feb 1, 1987·Neurology·B R ChambersV C Hachinski
Dec 14, 1995·The New England Journal of Medicine·UNKNOWN National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group
Jun 1, 1995·Drugs·M Verstraete, P Zoldhelyi
Jun 1, 1995·Stroke; a Journal of Cerebral Circulation·G R ThomasW F Bennett
Mar 1, 1995·Thrombosis Research·M A YenariG K Steinberg
Aug 1, 1994·Acta Neurologica Scandinavica·P MedenG Boysen
Mar 1, 1995·Stroke; a Journal of Cerebral Circulation·H HénonJ P Pruvo
Mar 1, 1995·Stroke; a Journal of Cerebral Circulation·P BratinaJ C Grotta
Nov 1, 1994·Stroke; a Journal of Cerebral Circulation·W G BarsanJ R Marler

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.