Intravenous Versus Oral Iron for the Treatment of Anemia in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Medicine
Stefanos BonovasSilvio Danese

Abstract

Anemia is the most prevalent extraintestinal complication of inflammatory bowel disease (IBD). Our aim was to evaluate the comparative efficacy and harm of intravenous (IV) versus oral iron supplementation for correcting anemia in adult IBD patients.We conducted a systematic review and meta-analysis to integrate evidence from randomized controlled trials having enrolled adults with IBD, and comparing IV versus oral iron (head-to-head) for correcting iron-deficiency anemia. Medline, Embase, Scopus, and the Web of Science database were searched through July 2015. The Cochrane Central Register of Controlled Trials, the WHO International Clinical Trials Registry Platform, the ClinicalTrials.gov, and international conference proceedings were also investigated. Two reviewers independently abstracted study data and outcomes, and rated each trial's risk-of-bias. Pooled odds ratio (OR) estimates with their 95% CIs were calculated using fixed- and random-effects models.Five eligible studies, including 694 IBD patients, were identified. In meta-analysis, IV iron demonstrated a higher efficacy in achieving a hemoglobin rise of ≥2.0 g/dL as compared to oral iron (OR: 1.57, 95% CI: 1.13, 2.18). Treatment discontinuation rates, due to adverse...Continue Reading

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References

Oct 1, 1992·International Journal of Epidemiology·D J Newell
Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Sep 28, 1998·JAMA : the Journal of the American Medical Association·M R Chassin, R W Galvin
Nov 10, 2000·Lancet·I R Edwards, J K Aronson
Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Apr 30, 2004·Statistics in Medicine·Michael J SweetingPaul C Lambert
Jul 13, 2004·Gut·C GascheG Weiss
Sep 17, 2005·Scandinavian Journal of Gastroenterology·Kari ErichsenTrygve Hausken
Nov 15, 2005·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·William B ErshlerRobert Dubois
Apr 26, 2008·BMJ : British Medical Journal·Gordon H GuyattUNKNOWN GRADE Working Group
May 15, 2008·The American Journal of Gastroenterology·Javier P Gisbert, Fernando Gomollón
Jul 23, 2009·Annals of Internal Medicine·David MoherUNKNOWN PRISMA Group
Sep 30, 2009·World Journal of Gastroenterology : WJG·Fernando Gomollón, Javier P Gisbert
Jan 7, 2010·Nature Reviews. Gastroenterology & Hepatology·Ellen Stein, Philip O Katz
Oct 7, 2010·Nature Reviews. Gastroenterology & Hepatology·Jürgen SteinAxel U Dignass
Jan 7, 2011·Journal of Clinical Epidemiology·Howard BalshemGordon H Guyatt
Oct 20, 2011·BMJ : British Medical Journal·Julian P T HigginsUNKNOWN Cochrane Statistical Methods Group
Oct 9, 2013·European Journal of Gastroenterology & Hepatology·Jürgen SteinSilvio Danese
Dec 18, 2014·Journal of Crohn's & Colitis·Axel U DignassUNKNOWN European Crohn’s and Colitis Organisation [ECCO]
Apr 7, 2015·Inflammatory Bowel Diseases·Anita Abhyankar, Alan C Moss
Jun 21, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Gionata FiorinoSilvio Danese

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Citations

Feb 13, 2017·The Medical Clinics of North America·Thomas G DeLoughery
Sep 20, 2017·The Annals of Pharmacotherapy·Anna Butcher
May 15, 2019·European Journal of Gastroenterology & Hepatology·Grace H TangChristine Brezden-Masley
May 6, 2020·International Journal of Clinical Pharmacy·Carla Valéria de Alvarenga AntunesJulio Maria Fonseca Chebli
May 23, 2020·Journal of Clinical Medicine·Ferdinando D'AmicoSilvio Danese
May 10, 2020·Advances in Nutrition·Ajibola I AbioyeWafaie W Fawzi
Feb 23, 2019·Expert Review of Gastroenterology & Hepatology·Ayşegül AksanJürgen Stein
Dec 8, 2017·Gastroenterology Research and Practice·Svein Oskar FrigstadPer M Hellström
Dec 14, 2018·Nutrients·Carla J Gargallo-PuyueloFernando Gomollon
Nov 18, 2020·Nutrients·Aditi Kumar, Matthew J Brookes
Dec 8, 2020·Lancet·Sant-Rayn PasrichaDorine W Swinkels
May 24, 2020·The Journal of Pediatrics·Amanda E Jacobson-KellySarah H O'Brien
Feb 2, 2021·Gastroenterology Clinics of North America·Alexa N SassonAshwin N Ananthakrishnan
Mar 9, 2021·Anaesthesia·C S BensonA A Klein
Feb 27, 2021·Health Technology Assessment : HTA·Toby RichardsAndrew Klein
Mar 30, 2021·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Lucia CococcioniOsvaldo Borrelli
May 1, 2021·Nutrients·Lorenzo BertaniFrancesco Costa
Apr 29, 2021·Scandinavian Journal of Medicine & Science in Sports·Anu Elisa Koivisto-MørkGøran Paulsen
Apr 11, 2019·Acta Haematologica·Kristine Michelle Jimenez, Christoph Gasche

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Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.