Intravenous vs. intraosseous administration of drugs during cardiac arrest: A systematic review.

Resuscitation
Asger GranfeldtLars W Andersen

Abstract

To perform a systematic review of the literature on intravenous (IV) vs. intraosseous (IO) administration of drugs during cardiac arrest in order to inform an update of international guidelines. The review was performed according to PRISMA guidelines and registered on PROSPERO. Medline, Embase and Evidence-Based Medicine Reviews were searched on December 17, 2019 for studies comparing IV to IO administration of drugs. The population included neonatal, paediatric, and adult patients with cardiac arrest. Two investigators reviewed each search for study relevance, extracted data, and assessed the risk of bias of individual studies. Meta-analyses were performed for studies without a critical risk of bias. Certainty of evidence was evaluated using GRADE. We included six observational studies comparing IV to IO administration of drugs and two randomized trials assessing the effect of specific drugs in subgroups related to IV vs. IO administration. All studies included adult out-of-hospital cardiac arrest patients. No studies were identified in neonatal or paediatric patients. The risk of bias for the observational studies was overall assessed as critical or serious, with confounding and selection bias being the primary sources of bia...Continue Reading

Citations

Apr 30, 2020·Current Opinion in Critical Care·Mikael F VallentinLars W Andersen
Oct 22, 2020·Circulation·Raina M MerchantUNKNOWN Adult Basic and Advanced Life Support, Pediatric Basic and Advanced Life Support, Neonatal Life Support, Resuscitation Educa
Feb 13, 2021·Resuscitation·J P NolanJ Soar
Jan 13, 2021·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Morgan RecherStéphane Leteurtre
Mar 29, 2021·Resuscitation·Patrick Van de VoordeIan Maconochie
Apr 2, 2021·Trauma Surgery & Acute Care Open·Ben E BiesterveldHasan B Alam
Mar 29, 2021·Resuscitation·Jasmeet SoarJerry P Nolan
Apr 17, 2021·Health Technology Assessment : HTA·Gavin D PerkinsRanjit Lall
Jun 8, 2021·Notfall & Rettungsmedizin·Patrick Van de VoordeIan Maconochie
Jun 18, 2021·The American Journal of Emergency Medicine·David E ZimmermanMegan A Rech
Jun 15, 2021·Notfall & Rettungsmedizin·Jasmeet SoarJerry P Nolan
Aug 4, 2021·Critical Care Nursing Clinics of North America·Justin DiLibero, Kara Misto
Aug 11, 2021·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·J ThannhauserM J de Boer

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