PMID: 1731011Jan 1, 1992Paper

Intravenously administered labetalol for treatment of hypertension in children

The Journal of Pediatrics
T E BunchmanE G Wood

Abstract

Thirteen children (ages 9.2 +/- 3.7 years, mean +/- SD) received intravenous doses of labetalol, an alpha 1- and beta-adrenergic blocker, on 15 separate occasions for treatment of hypertension. In 12 of 15 episodes an initial dose of 0.55 +/- 0.34 mg/kg was given; in all 15 a continuous infusion of 0.78 +/- 0.39 mg/kg per hour was utilized for 67.3 +/- 57.1 hours. A significant decrease in systemic blood pressure occurred in all episodes (143/99.1 +/- 17.7/11.1 vs 115.6/72.4 +/- 7.7/9.5; p less than 0.01). A clinically unimportant yet statistically significant decrease in heart rate occurred during labetalol infusion (116.3 +/- 19.8 vs 107.8 +/- 11 beats/min; p less than 0.01). The episodes in children with creatinine clearances greater than 50 (n = 6) were compared with those with creatine clearances less than 20 ml/min per 1.73 m2 (n = 9); similar doses of labetalol were required for control of blood pressure. We conclude that infusion of labetalol is effective for control of blood pressure in children with hypertension, regardless of renal function.

References

Oct 1, 1990·The Journal of Pediatrics·T WellsG L Kearns
Aug 1, 1990·Annals of Internal Medicine·J A ClarkL A Tanner
Sep 1, 1981·Journal of Cardiovascular Pharmacology·C BarbieriA Bertazzoni
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Citations

Oct 8, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Joseph T Flynn, Kjell Tullus
Jul 21, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jayanthi Chandar, Gastón Zilleruelo
Mar 12, 2011·International Journal of Clinical Pharmacy·D G HornG Hempel
Jul 3, 2002·Current Treatment Options in Cardiovascular Medicine·Craig W Belsha
Mar 11, 2000·Pharmacotherapy·M E Temple, Milap C Nahata
Mar 22, 2005·Paediatric Drugs·Renee F RobinsonJohn D Mahan
Jan 29, 2011·Indian Journal of Pediatrics·Pankaj Hari, Aditi Sinha
Jan 15, 2008·Annals of Emergency Medicine·Craig W Belsha
Dec 12, 2000·Journal of Pediatric Health Care : Official Publication of National Association of Pediatric Nurse Associates & Practitioners·I Porto
Nov 28, 2013·Pharmaceuticals·Joseph D TobiasSergio D Bergese
Jan 19, 2011·Journal of Cardiovascular Pharmacology·Joseph T Flynn
Apr 1, 2005·Current Opinion in Pediatrics·Hiren P Patel, Mark Mitsnefes
May 25, 2010·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Christopher A ThomasDaniel I Feig
Sep 6, 2011·Paediatric Drugs·Christopher A Thomas
Sep 2, 2018·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Abanti Chaudhuri, Scott M Sutherland
Sep 12, 2020·Pediatric Cardiology·Joseph D TobiasCatherine D Krawczeski
Apr 25, 2021·Indian Journal of Pediatrics·Sheetal LadSuresh Kumar Angurana

Related Concepts

Teens
Krebiozen
Proglycem
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Hypertensive Disease
Intravenous Infusion Procedures
Presolol
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Nitriate

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