Intravenously delivered multilineage-differentiating stress enduring cells dampen excessive glutamate metabolism and microglial activation in experimental perinatal hypoxic ischemic encephalopathy.

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Toshihiko SuzukiMasahiro Hayakawa

Abstract

Perinatal hypoxic ischemic encephalopathy (HIE) results in serious neurological dysfunction and mortality. Clinical trials of multilineage-differentiating stress enduring cells (Muse cells) have commenced in stroke using intravenous delivery of donor-derived Muse cells. Here, we investigated the therapeutic effects of human Muse cells in an HIE model. Seven-day-old rats underwent ligation of the left carotid artery then were exposed to 8% oxygen for 60 min, and 72 hours later intravenously transplanted with 1 × 104 of human-Muse and -non-Muse cells, collected from bone marrow-mesenchymal stem cells as stage-specific embryonic antigen-3 (SSEA-3)+ and -, respectively, or saline (vehicle) without immunosuppression. Human-specific probe revealed Muse cells distributed mainly to the injured brain at 2 and 4 weeks, and expressed neuronal and glial markers until 6 months. In contrast, non-Muse cells lodged in the lung at 2 weeks, but undetectable by 4 weeks. Magnetic resonance spectroscopy and positron emission tomography demonstrated that Muse cells dampened excitotoxic brain glutamatergic metabolites and suppressed microglial activation. Muse cell-treated group exhibited significant improvements in motor and cognitive functions at 4...Continue Reading

References

May 10, 2000·Seminars in Neonatology : SN·M V JohnstonW Nakajima
Oct 14, 2005·The New England Journal of Medicine·Seetha ShankaranUNKNOWN National Institute of Child Health and Human Development Neonatal Research Network
Apr 28, 2010·Proceedings of the National Academy of Sciences of the United States of America·Yasumasa KurodaMari Dezawa
Jun 2, 2011·Proceedings of the National Academy of Sciences of the United States of America·Shohei WakaoMari Dezawa
Sep 28, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Qi GuoRoger N Gunn
Oct 17, 2013·Pediatrics International : Official Journal of the Japan Pediatric Society·Masahiro HayakawaUNKNOWN Executive Committee, Symposium on Japan Society of Perinatal and Neonatal Medicine
Nov 14, 2013·Clinical & Developmental Immunology·Roslyn A Taylor, Lauren H Sansing
Jan 7, 2015·Stem Cells Translational Medicine·Kahori KinoshitaKotaro Yoshimura
Jul 4, 2015·Cell Stem Cell·Alan Trounson, Courtney McDonald
Aug 27, 2016·Brain, Behavior, and Immunity·Zhiqian YuHiroaki Tomita
Dec 22, 2016·Stroke; a Journal of Cerebral Circulation·Hiroki UchidaMari Dezawa
Mar 11, 2017·Scientific Reports·Keiko NakanishiYujiro Higashi
May 12, 2017·Tissue Engineering. Part B, Reviews·Yao FuMarcel Karperien
Jul 5, 2017·Journal of the American Society of Nephrology : JASN·Nao UchidaMari Dezawa
Dec 21, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Catherine McCaigAtticus H Hainsworth
Oct 20, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Gina HadleyAlastair M Buchan
Oct 31, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Cesar V BorlonganEleonora Napoli
Nov 22, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Patrick D LydenPadmesh S Rajput
Nov 30, 2018·Advances in Experimental Medicine and Biology·Yoshihiro KushidaMari Dezawa

❮ Previous
Next ❯

Citations

Jun 5, 2021·Brain Circulation·You Jeong ParkMari Dezawa
Jul 1, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·You Jeong Park, Cesar V Borlongan

❮ Previous
Next ❯

Software Mentioned

JMP Pro
ARRIVE
SPSS

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Related Papers

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
Emiko HoriSatoshi Kuroda
Postgraduate Medicine
R Armour
Postgraduate Medicine
R Armour
© 2021 Meta ULC. All rights reserved