PMID: 41277Sep 1, 1979

Intraventricular self-administration of acetaldehyde, but not ethanol, in naive laboratory rats

Z W BrownG E Rockman


For 11 consecutive days, naive rats were maintained in operant chambers where they were given the opportunity to self-administer acetaldehyde (1,2, or 5% v/v), ethanol (2 or 10% v/v), or pH control solutions directly into the cerebral ventricles. Only the animals that had access to the 2 and 5% acetaldehyde solutions showed rates of lever pressing significantly higher than controls. It is suggested that acetaldehyde rather than ethanol itself may mediate the positive reinforcing effects of ethanol in the brain.


Jan 1, 1991·Psychopharmacology·Carlos M G AragonZ Amit
Nov 26, 2009·Psychopharmacology·Elysia SmallAdrie W Bruijnzeel
Jul 1, 1993·Biological Psychiatry·T L WallC L Ehlers
Jun 15, 1983·Toxicology and Applied Pharmacology·M A Green, J L Egle
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Mar 1, 1985·Alcohol·S M SocaranskyZ Amit
Mar 20, 2002·Pharmacology, Biochemistry, and Behavior·Zachary A Rodd-HenricksTing-Kai Li
Aug 5, 2003·Pharmacology, Biochemistry, and Behavior·Amir H RezvaniMaurizio Massi
Aug 27, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Maria N Arizzi-LaFranceJohn D Salamone
Sep 20, 2012·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Allison C Hoffman, Sarah E Evans
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Nov 6, 2007·Alcohol·Michael E NizhnikovNorman E Spear
Mar 27, 2007·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Reinskje TalhoutJan G C van Amsterdam
Feb 17, 2005·Alcoholism, Clinical and Experimental Research·Etienne QuertemontMarco Diana
Jul 28, 2005·Alcoholism, Clinical and Experimental Research·Laura FontCarlos M G Aragon
Sep 13, 2005·Alcoholism, Clinical and Experimental Research·Etienne QuertemontRoberta J Ward
May 1, 2008·Alcoholism, Clinical and Experimental Research·Lutske TampierYedy Israel


May 15, 1976·Biochemical Pharmacology·G Cohen
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Oct 4, 1968·Science·N H Raskin, L Sokoloff
Aug 1, 1974·Journal of Neurochemistry·H W Sippel
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Dec 25, 1948·Lancet·J HALD, E JACOBSEN

Related Concepts

Brain Chemistry
Self Administration
Hydrogen-Ion Concentration
Injections, Intraventricular

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