PMID: 9660271Jul 11, 1998Paper

Intraventricular streptokinase infusion in acute post-haemorrhagic hydrocephalus

Intensive Care Medicine
R LucianoG Polidori

Abstract

Neonatal post-haemorrhagic hydrocephalus is a clinical condition with a high mortality and long-term morbidity. Its clinical management is difficult and not well standardized. We describe the case of a term baby suffering from acute intracranial hypertension caused by an intraventricular and thalamic haemorrhage. In this case, the external ventricular drain inserted to control intracranial pressure was ineffective because of repeated obstructions due to blood clots. Continuous intraventricular infusion of streptokinase of 20,000 U/day allowed quick lysis of the clots, drainage of the cerebrospinal fluid and relief from the coma. Although it did not prevent a permanent ventriculoperitoneal shunt, we obtained reabsorption of the intraventricular haemorrhage without rebleeding complications. We suggest the use of low-dose fibrinolytic infusion through an external drain for the treatment of acute intracranial hypertension following intraventricular haemorrhage in term infants.

Citations

Jun 10, 2004·Critical Care Medicine·Mary-Beth MalayDonald W Landry
Aug 10, 2005·Expert Opinion on Pharmacotherapy·Maria A Poca, Juan Sahuquillo
May 20, 2015·Journal of Neurosurgery. Pediatrics·Catherine A MazzolaUNKNOWN Pediatric Hydrocephalus Systematic Review and Evidence-Based Guidelines Task Force

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.