Intraventricular vs intrathecal baclofen for secondary dystonia: a comparison of complications.

Neurosurgery
Brandon G Rocque, A Leland Albright

Abstract

Intrathecal baclofen (ITB) is an effective treatment for secondary dystonia. However, in many patients with dystonia, placement of an intrathecal catheter is difficult because of anatomic anomalies or spinal fusion. Intraventricular baclofen (IVB) has been shown to be an effective alternate route for drug delivery in a small series of patients. To present the largest series of IVB cases to date and to compare the complication rate with that of a concurrent cohort of ITB cases. The senior author's series of IVB cases were reviewed. All contemporaneous cases of ITB for dystonia were reviewed as a control group. Data were collected by retrospective medical records review. Thirty IVB patients and 33 ITB patients were identified. Mean follow-up was 15 and 16 months, respectively. IVB patients were younger, were more commonly underweight, and had more severe dystonia, although no difference between groups was significant. Eleven patients (37%) in the IVB group and 16 patients (48%) in the ITB group experienced complications. Kaplan-Meier survival analysis showed an odds ratio of 0.67 (95% confidence interval, 0.30-1.48; P = .31) in favor of IVB. Adjusting for age and underweight status yielded an odds ratio of 0.64 (95% confidence in...Continue Reading

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Citations

Oct 22, 2013·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Mary Ann Thenganatt, Joseph Jankovic
Jun 4, 2014·Archives of Physical Medicine and Rehabilitation·Herre W HeetlaTeus van Laar
Jan 27, 2018·Journal of Neurosurgery. Pediatrics·Zaid AljubooriAndrew Jea
Oct 6, 2012·Movement Disorders : Official Journal of the Movement Disorder Society·Travis S Tierney, Andres M Lozano
Dec 13, 2016·Journal of Physical Therapy Science·Eom-Ji ParkSoohee Park
Mar 13, 2020·Frontiers in Neurology·Rui-Zhe ZhengGuang-Ming Zhang

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