Abstract
We performed a prospective, randomized, controlled study to compare intravesical epirubicin and doxorubicin as adjuvant therapy after endoscopic resection of superficial bladder tumor. We randomly allocated 253 eligible patients to 4 study arms. Seven to 14 days after transurethral bladder tumor resection instillation of the intravesical agent was instituted, including 50 and 80 mg. epirubicin in study arms 1 and 2, respectively, and 50 mg. doxorubicin in arm 3. Control arm 4 included patients who underwent transurethral bladder tumor resection alone. Instillation was repeated weekly for 8 weeks and monthly thereafter to complete 1 year of treatment. All patients were followed every 3 months by cystourethroscopy, urine cytology and deoxyribonucleic acid flow cytometry for 12 to 48 months (mean 30.1). Rates of recurrence were significantly lower in the chemotherapy groups than in controls (p < 0.001) and in the epirubicin groups than in the doxorubicin group (p = 0.02). In arms 1 to 4 recurrence rates were 25, 17.6, 36.7 and 65.6%, respectively. Recurrence rates per 100 patient months were 0.83, 0.60, 1.18 and 2.73, respectively, which were significant statistically, and lower after chemotherapy in general and epirubicin in part...Continue Reading
References
Jan 1, 1992·Cancer Chemotherapy and Pharmacology·A P van der MeijdenF M Debruyne
Aug 1, 1991·British Journal of Urology·J T RobertsM K Parmar
Dec 1, 1991·The Journal of Urology·K KurthI Van Reyswoud
May 1, 1991·The Journal of Urology·B E CarbinB Sandstedt
Jun 1, 1991·British Journal of Urology·P WhelanP H Smith
Jan 1, 1990·European Urology·J A CummingP Whelan
Sep 1, 1988·British Journal of Urology·P D AbelG Williams
Dec 1, 1987·The Journal of Urology·H W HerrW F Whitmore
Jan 1, 1986·Cancer Chemotherapy and Pharmacology·Y MatsumuraH Ohmori
Sep 1, 1986·The Journal of Urology·E D CrawfordM Duchek
Aug 1, 1984·The Journal of Urology·K H KurthF ten Kate
Mar 1, 1983·The Journal of Urology·H ZinckeF J Leary
Jan 1, 1983·Cancer Chemotherapy and Pharmacology·T NiijimaH Akaza
Jan 1, 1983·Cancer Chemotherapy and Pharmacology·Y MatsumuraH Ohmori
Dec 1, 1983·British Journal of Urology·G SmithT B Hargreave
Jan 1, 1984·The Journal of Urology·M B GarnickJ P Richie
Apr 1, 1980·The Journal of Urology·M S Soloway
Jan 1, 1980·European Urology·F EdsmyrL G Collste
Jun 1, 1980·Urology·T UyamaS Kagawa
Jul 1, 1980·The Journal of Urology·G H Jacobi, K H Kurth
Jan 1, 1994·Cancer Chemotherapy and Pharmacology·N ShinoharaA Maru
Jan 1, 1994·Cancer Chemotherapy and Pharmacology·N WatanabeN Hanamoto
Sep 1, 1993·Cancer·M D MelekosH H Dauaher
Apr 1, 1993·The Journal of Urology·W OosterlinckR Sylvester
Apr 1, 1980·Cancer·Mark S Soloway
Citations
Oct 2, 2009·Der Urologe. Ausg. A·J SimonL Rinnab
Aug 6, 2003·Critical Reviews in Oncology/hematology·Per-Uno Malmström
May 8, 2007·Nature Clinical Practice. Urology·Guido Dalbagni
Dec 4, 2002·BJU International·R T Bryan, D M A Wallace
May 2, 2000·Anti-cancer Drugs·S EksborgO Björk
Nov 1, 2007·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Jablan StankovićSvetlana Pavlović
Mar 17, 2015·Expert Opinion on Pharmacotherapy·Sanjay G PatelGary D Steinberg
Apr 2, 2013·The Urologic Clinics of North America·Joshua G Griffin, Jeff Holzbeierlein
Oct 9, 2012·Seminars in Oncology·Vinod H NargundM N Kabir
Jan 22, 2008·European Urology·Richard J SylvesterJ Alfred Witjes
Aug 22, 2003·BJU International·B Ali-El-DeinM A Ghoneim
Jun 26, 2012·International Journal of Urology : Official Journal of the Japanese Urological Association·Yuta YamadaYukio Homma
Dec 11, 2003·The Journal of Urology·Hirofumi KogaSeiji Naito
May 16, 2006·The Journal of Urology·Madhusudan P KoyaMark S Soloway
Mar 26, 2002·The Journal of Urology·Mark S SolowayAnil Vaidya
Jul 20, 1999·The Journal of Urology·B Ali-El-DeinM A Ghoneim
Mar 4, 2000·The Urologic Clinics of North America·J L Duque, K R Loughlin
May 3, 2005·The Urologic Clinics of North America·Michael A O'Donnell
Apr 14, 2009·Urology·Juan PalouHumberto Villavicencio
Jan 27, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xiaheng DengChangjun Yin
Jun 24, 2015·TheScientificWorldJournal·Tomonori KatoAkira Komiya
Mar 22, 2015·Der Urologe. Ausg. A·M Schenck, G Lümmen
Sep 28, 2016·Photodiagnosis and Photodynamic Therapy·E V FilonenkoA N Urlova
May 8, 2018·Expert Opinion on Emerging Drugs·Jasper Crijnen, Theo M De Reijke
Oct 13, 2006·Current Opinion in Urology·S B Malkowicz
Jan 24, 2017·Cancer·Vignesh T PackiamGary D Steinberg
Oct 12, 2018·Indian Journal of Pathology & Microbiology·Noha ElkadyEnas Elkhouly
Nov 13, 2020·Urology·George E KochSam S Chang