Intravesical hyaluronic acid and alkalinized lidocaine for the treatment of severe painful bladder syndrome/interstitial cystitis.

International Urogynecology Journal
Yi-Song LvXue-Yi Xue

Abstract

Intravesical instillation of hyaluronic acid (HA) may restore the integrity of glycosaminoglycan layer in patients with painful bladder syndrome/interstitial cystitis (PBS/IC), and the benefit may be improved with addition of alkalinized lidocaine (AL). 48 women with severe PBS/IC who failed oral medications were enrolled and divided into one trial and two control groups. The trial group received intravesical 40 mg HA, 10 ml of 2 % lidocaine and 5 ml of 8.4 % sodium bicarbonate on a weekly basis for 8 weeks and then monthly for 4 months with a subsequent follow-up of 24 weeks, while the two control groups received 40 mg HA and mixture of 10 ml of 2 % lidocaine and 5 ml of 8.4%sodium bicarbonate respectively following the same procedure. Response to therapy was evaluated by Global Response Assessment, voids per day, Visual Analogue Scale for pain, frequency and urgency, O'leary-Sant Interstitial Cystitis Symptom Index and Problem Index, cystoscopy and bladder capacity. Overall 45 patients finished this study protocol. The HA + AL group and the AL group showed significant improvement at week 2 (P < 0.01), while the HA group began to show effect at week 4 (P < 0.01). There was no improvement in the AL group at week 24 and these pa...Continue Reading

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Citations

Jul 26, 2012·Current Urology Reports·Renee B Quillin, Deborah R Erickson
Aug 27, 2014·Obstetrics and Gynecology Clinics of North America·Susan Barr
Feb 6, 2013·International Journal of Urology : Official Journal of the Japanese Urological Association·Yi-Song LvWei-Ping Hao
Aug 15, 2015·International Urogynecology Journal·Carolina PazinJulio Cesar Rosa-E-Silva
Mar 5, 2016·Expert Opinion on Investigational Drugs·Yao-Chi ChuangPradeep Tyagi
Nov 25, 2014·Current Infectious Disease Reports·Avinash ChennamsettyKim A Killinger
Sep 12, 2016·International Urogynecology Journal·Wei ZhangXu Wang
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Nov 30, 2013·International Journal of Urology : Official Journal of the Japanese Urological Association·Yi Song LvJian Huang
Jan 18, 2018·Lower Urinary Tract Symptoms·En MengYao-Chi Chuang
Jul 24, 2018·Therapeutic Advances in Urology·Esther HanKenneth Peters
Feb 15, 2014·Urologia·Elisabetta CostantiniMassimo Porena

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