Abstract
To evaluate and compare the efficacy of botulinum toxin intravesical injections with and without injections in external urethral sphincter in treating bladder hyper-reflexia in children suffering from myelomeningocele. A total of 60 patients with bladder hyper-reflexia due to myelomeningocele were randomly allocated to treatment groups A and B and were followed up for 6 months. Under cystoscopic guidance, 10 IU/kg of botulinum toxin A was injected into the detrusor muscle, sparing the trigone and ureteral orifices in group A. Group B received 8 IU/kg of toxin via the same method compared with group A and 2 IU/kg of toxin through 4 injections in external urethral sphincter. Conventional urodynamics, daily incontinence score, constipation, and creatinine level were evaluated at baseline, 3 months, and 6 months after intervention. Vesicoureteral reflux was also assessed before and after 3 months of injections. All patients showed significant improvement in bladder capacity (P <.01), maximal detrusor pressure (P <.01), and detrusor-sphincter dyssynergia (P <.01) after 3 and 6 months of receiving injections. Significant improvement in postvoiding residual volume was observed only among patients of group B (P <.05). Both methods resu...Continue Reading
References
Jan 1, 1985·Pediatric Radiology·R L LebowitzT E Tamminen-Möbius
Aug 3, 1984·JAMA : the Journal of the American Medical Association·S B BauerA B Retik
Jul 1, 1997·Neurology·R R SloopR O Escutin
Nov 2, 2002·Spinal Cord·J J Wyndaele, S A Van Dromme
Oct 16, 2003·The Journal of Urology·Alan J Wein
Jan 10, 2004·The Journal of Urology·Marcus RiccabonaStuart B Bauer
May 12, 2004·Urology·Hann-Chorng Kuo
Aug 18, 2004·The Urologic Clinics of North America·Warren T Snodgrass, Richard Adams
Nov 19, 2004·European Urology·A HaferkampM Stöhrer
Mar 1, 2005·Journal of Pediatric Gastroenterology and Nutrition·Marc BenningaAnnamaria Staiano
Jun 2, 2005·Current Opinion in Urology·Brigitte Schurch, Jacques Corcos
Jul 12, 2005·The Journal of Urology·Alan J Wein
Aug 12, 2005·The Journal of Urology·A ApostolidisP Anand
Nov 23, 2006·Urology·Abdol-Mohammad KajbafzadehFarideh Nejat
Sep 26, 2008·European Urology·Antonella GiannantoniMassimo Porena
Oct 1, 2008·European Urology·Apostolos ApostolidisUNKNOWN European Consensus Panel
Citations
Nov 19, 2013·European Urology·Altaf MangeraChristopher Chapple
Nov 1, 2011·Current Urology Reports·Gregory E Dean, Christopher Long
Oct 28, 2014·Expert Opinion on Biological Therapy·Eric Chung
Apr 30, 2011·The Journal of Urology·Maria Paola PascaliMario De Gennaro
Aug 12, 2015·Nature Reviews. Urology·Yuan-Hong JiangHann-Chorng Kuo
Feb 19, 2013·Toxicon : Official Journal of the International Society on Toxinology·Michael B ChancellorAnthony B Ward
May 18, 2016·Neurourology and Urodynamics·Juliette HascoetUNKNOWN French Referral Network of Spina Bifida
Oct 18, 2016·Current Opinion in Urology·Jeroen R ScheepeLisette A 't Hoen
Sep 7, 2017·Neurourology and Urodynamics·Giovanni PalleschiEnrico Finazzi Agrò
Mar 25, 2019·Urology Practice·Aaron KavianiRose Khavari
Jun 12, 2019·International Urology and Nephrology·Riyad PeeraullyNia Fraser
Jan 7, 2021·International Neurourology Journal·Yuan-Hong JiangHann-Chorng Kuo
Jul 3, 2021·Toxins·Shu-Yu WuChun-Kai Hsu