PMID: 6411163Aug 1, 1983Paper

Intravesical instillation of mitomycin C in the prophylactic treatment of recurring superficial transitional cell carcinoma of the bladder

British Journal of Urology
M DevonecJ M Dubernard

Abstract

Twenty-six patients with an elevated recurrence rate of stage O or A bladder tumours were treated prophylactically after transurethral resection (TUR) with short-term intravesical instillations of mitomycin C in a non-randomised study. The data before intravesical chemotherapy (IVC) were taken as the internal control for each patient. Mitomycin C was administered in one course of 10 daily doses of 40 mg, starting 24 to 48 hours after TUR. The average follow-up was 13.9 months before and 28.5 months after IVC. Before IVC, the average number of recurrences was 2.6, with an average recurrence rate of 1 every 5.3 months. After IVC there was no tumour recurrence in 4 patients, with a mean of 12.2 months' follow-up, but there was tumour recurrence in 22 patients. For 17 patients (77%) the free interval averaged 2.3 times longer than the mean interval of recurrence before IVC and for 18 patients (82%) the recurrence rate averaged 3.3 times less than the recurrence rate before IVC.

References

Aug 1, 1975·The Journal of Urology·T MishinaY Mori
May 1, 1981·The Journal of Urology·M S SolowayP Finebaum

❮ Previous
Next ❯

Citations

Jan 1, 1994·Cancer Chemotherapy and Pharmacology·A V Bono
Aug 1, 1992·British Journal of Urology·R MigliariE Usai
Dec 1, 1985·British Journal of Urology·G G HadjissotiriouG D Chisholm
Jan 1, 1985·Cancer Drug Delivery·H J Keizer, H M Pinedo
Feb 15, 2001·The Journal of Urology·J C Kim, G D Steinberg
Aug 9, 2011·Cancer·Karim ChamieUNKNOWN Urologic Diseases in America Project
Mar 10, 2001·Cancer Treatment Reviews·W T Bradner

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.