Intravesical mycobacterial cell wall-DNA complex in the treatment of carcinoma in situ of the bladder after standard intravesical therapy has failed

The Journal of Urology
Alvaro MoralesGary Steinhoff

Abstract

We assessed the clinical efficacy and safety of mycobacterial cell wall-DNA complex after intravesical administration in patients with carcinoma in situ in whom prior therapy with bacillus Calmette-Guerin failed or in those who were treatment naïve. Patients received 6 weekly instillations of 4 or 8 mg mycobacterial cell wall-DNA complex (formulated as an emulsion) followed by 3 weekly instillations at weeks 12 and 24. Efficacy and safety were evaluated throughout the treatment phase and at months 12 and 18. A total of 55 patients (mean age 74 years, 74.6% male) received 4 mg (25) or 8 mg (30) mycobacterial cell wall-DNA complex emulsion. All patients were previously treated with bacillus Calmette-Guerin except for 8 who were treatment naïve and 2 who received chemotherapy. In the intent to treat population the complete response rate was 27.3% at weeks 12 and 26 in the 4 mg group while 46.4% of patients receiving 8 mg had a complete response at both points. Mycobacterial cell wall-DNA complex was well tolerated by both dose groups. Overall 90% of all adverse events were mild to moderate in severity. Mycobacterial cell wall-DNA complex has shown antineoplastic activity in patients with bladder cancer with less toxicity than that...Continue Reading

References

Feb 15, 2001·The Journal of Urology·J C Kim, G D Steinberg
Oct 5, 2001·The Journal of Urology·A MoralesE W Ramsey
Jan 5, 2002·Expert Opinion on Investigational Drugs·M C Filion, N C Phillips
Sep 17, 2003·Toxicology and Industrial Health·John F RisherGeorge R Prince
Jul 22, 2004·British Journal of Cancer·R F M BeversD H J Schamhart
Feb 9, 2006·European Urology·Johannes A Witjes
Jun 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Guido DalbagniDean Bajorin
Oct 6, 2006·World Journal of Urology·Michael A O'Donnell, Andreas Boehle
Nov 23, 2006·Journal of the National Comprehensive Cancer Network : JNCCN·Stephen A Brassell, Ashish M Kamat
Oct 24, 2007·European Urology·Jesus Fernandez-GomezUNKNOWN Club Urológico Español de Tratamiento Oncológico (CUETO)

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Citations

Feb 5, 2013·Current Urology Reports·LaMont J Barlow, Mitchell C Benson
Feb 13, 2010·Current Opinion in Oncology·Todd M Morgan, Peter E Clark
Jul 20, 2010·Immunotherapy·Shahrokh F ShariatGuido Dalbagni
Sep 19, 2014·Expert Review of Anticancer Therapy·Yonghua WangXinsheng Wang
Oct 31, 2013·Expert Review of Anticancer Therapy·Anna V van LingenJ Alfred Witjes
Dec 23, 2011·Expert Opinion on Investigational Drugs·Vladimir Yutkin, Joseph Chin
Aug 21, 2013·Expert Opinion on Biological Therapy·Anna V van Lingen, J Alfred Witjes
Jan 19, 2010·Expert Opinion on Investigational Drugs·Marc C SmaldoneJeffrey R Gingrich
Apr 2, 2013·The Urologic Clinics of North America·Jennifer J Ahn, James M McKiernan
Mar 12, 2015·Current Treatment Options in Oncology·Philip L HoAshish M Kamat
Dec 24, 2009·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Daher C ChadeGuido Dalbagni
Jun 13, 2014·Current Opinion in Urology·Jennifer J AhnJames M McKiernan
Mar 11, 2017·Current Opinion in Oncology·Mark D TysonPeter Clark
Dec 2, 2015·Therapeutic Advances in Urology·Dominic H Tang, Sam S Chang
Jan 31, 2018·Frontiers in Pharmacology·Julieti Huch BussFabiana Kömmling Seixas
Jun 2, 2016·Therapeutic Advances in Urology·Akhil MuthigiPiyush K Agarwal
Jan 19, 2018·Indian Journal of Urology : IJU : Journal of the Urological Society of India·Kareem N RaynPiyush K Agarwal
Feb 15, 2019·Current Opinion in Urology·Melanie R HasslerFrancesco Soria
Aug 28, 2013·Nature Reviews. Urology·Hélène LaRueYves Fradet
Jun 6, 2009·Expert Review of Anticancer Therapy·Frances M Martin, Ashish M Kamat
Aug 16, 2019·Expert Opinion on Investigational Drugs·Jennifer TseVitaly Margulis
Jul 31, 2012·Current Opinion in Urology·Ja H Ku, Seth P Lerner
Jul 24, 2014·Molecular and Clinical Oncology·Michael D WeintraubPiyush K Agarwal
Mar 16, 2016·Current Opinion in Oncology·Kristen R ScarpatoPeter E Clark
Oct 1, 2019·Current Opinion in Urology·Francesca PisanoJ Palou
May 21, 2015·American Society of Clinical Oncology Educational Book·Sam J BrancatoPiyush K Agarwal
Nov 13, 2021·Future Oncology·Samantha R Unsworth-WhiteRichard T Bryan

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