Intravesical oxybutynin protects the vesical wall against functional and smooth muscle changes in rabbits with detrusor overactivity.

International Urogynecology Journal
Armando Polido JúniorJoão Luiz Amaro

Abstract

The aim of this study was to evaluate the protective effect of intravesical oxybutynin on the bladder wall of rabbits with detrusor overactivity and partial bladder outlet obstruction (PBOO). Forty-five North Folk male rabbits were randomly distributed into GI, used as control (n = 15), GII-PBOO (n = 14), and GIII-PBOO + intravesical oxybutynin (n = 15). Connective tissue and elastic fibers were quantified as volumetric density on picrosirius red and Weigert's Fuchsin-Resorcin-stained sections, respectively. In T2, bladder weight was significantly higher in animals in GII and GIII. Smooth muscle bundle diameter was increased by 42% in GII compared with GI (p < 0.02).Elastic fibers were significantly higher in GII and GIII as compared with control group. Collagen concentration in GIII and GII was significantly lower than G1 (p < 0.025). Intravesical oxybutynin protected against structural and functional detrusor modifications of the partially obstructed bladder.

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Citations

Sep 24, 2013·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Nevzat Can SenerM Imamoglu Abdurrahim
Nov 2, 2011·Acta Cirúrgica Brasileira·Silvio TucciAntonio Carlos Pereira Martins

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