Intravital imaging of anti-tumor immune response and the tumor microenvironment.

Seminars in Immunopathology
Tomasz Zal, Grzegorz Chodaczek

Abstract

Tumor growth, invasiveness, and metastasis are dynamic processes involving cancer interactions with the extracellular matrix, the vasculature, and various types of non-cancerous host cells that form the tumor stroma. An often-present stromal component is the immune cells, such as tumor-associated myeloid and lymphocytic infiltrates, yet endogenous anti-tumor immune responses are typically ineffective in tumor rejection and may even contribute to the progression of some cancers. How exactly cancer cells interact with the stroma and invade healthy tissues while avoiding anti-tumor immune responses, and which interactions should be targeted for anti-tumor therapy, can now be studied by minimally invasive observation using multiphoton and other low impact confocal microscopy techniques and fluorescent animal tumor models. Intravital video microscopy has already been instrumental in defining the roles and modes of cellular motility in the angiogenic process and during tissue invasion at the tumor margin. In the hands of cancer immunologists, intravital video microscopy is beginning to unravel the complexity of effector and suppressory lymphocytic interactions in tumors and in the draining lymphoid organs. As the intravital microscop...Continue Reading

References

Nov 1, 1979·Microvascular Research·H D PapenfussF A Treese
Jan 1, 1984·Experimental Cell Biology·K H FalkvollP Marton
Oct 1, 1996·Proceedings of the National Academy of Sciences of the United States of America·C XuW W Webb
Jul 17, 1998·Experimental Cell Research·J B WyckoffJ E Segall
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·A MiyawakiR Y Tsien
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
Nov 7, 2000·Genesis : the Journal of Genetics and Development·T MotoikeT N Sato
Apr 20, 2001·Annals of Medicine·J Myllyharju, K I Kivirikko
Apr 20, 2002·Biophysical Journal·Shaohui HuangWatt W Webb
May 23, 2002·Biophysical Journal·Patrick StollerAlexander M Rubenchik
Aug 15, 2002·Proceedings of the National Academy of Sciences of the United States of America·Aikaterini ZoumiBruce J Tromberg
Oct 31, 2002·Nature Immunology·Gavin P DunnRobert D Schreiber
Nov 5, 2002·Nature Reviews. Immunology·Michael D CahalanMark J Miller
Dec 21, 2002·Differentiation; Research in Biological Diversity·Vito Quaranta
Mar 4, 2003·Nature Immunology·Jason D FontenotAlexander Y Rudensky
May 2, 2003·Nature Reviews. Cancer·Peter Friedl, Katarina Wolf
Apr 8, 2004·International Journal of Cancer. Journal International Du Cancer·Selman AliNicola Brown
Feb 12, 2005·Journal of Applied Physiology·Wayne J E LammRobb W Glenny
Oct 11, 2005·Annual Review of Cell and Developmental Biology·Cornelia HalinUlrich H von Andrian
Feb 9, 2006·Current Opinion in Immunology·Karl S PeggsJames P Allison
Nov 23, 2006·The Journal of Experimental Medicine·Paulus MrassWolfgang Weninger
Nov 28, 2006·Frontiers in Bioscience : a Journal and Virtual Library·Peter G BushAndrew C Hall
Dec 28, 2006·BMC Medicine·Paolo P ProvenzanoPatricia J Keely
Jan 31, 2007·The Journal of Experimental Medicine·Alexandre BoissonnasSebastian Amigorena
Feb 27, 2007·Nature·Henrique Veiga-FernandesDimitris Kioussis
Mar 17, 2007·Cancer Research·Jeffrey B WyckoffJohn Condeelis
Jun 7, 2007·Journal of Bioenergetics and Biomembranes·Zhao ChenPeng Huang
Jul 31, 2007·Journal of Bioenergetics and Biomembranes·Ramon Bartrons, Jaime Caro
Sep 19, 2007·Laboratory Investigation; a Journal of Technical Methods and Pathology·Ramana VishnubhotlaSarah C Glover
Nov 29, 2007·Proceedings of the National Academy of Sciences of the United States of America·Melissa C SkalaNirmala Ramanujam
Jan 30, 2008·Current Protocols in Cell Biology·Dmitriy KedrinJeffrey E Segall

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Citations

Jan 20, 2012·Annals of Biomedical Engineering·Seth W PerryEdward B Brown
Jun 28, 2012·Journal of Toxicology·Brittany UmerMing Q Wei
Nov 19, 2011·Immunotherapy·Janos RoszikLaurence J N Cooper
Jun 9, 2016·The Journal of Experimental Medicine·Sara McArdleKlaus Ley
Jun 8, 2015·The Cancer Journal·Valerie S LeBleu
Feb 16, 2017·Frontiers in Oncology·Nirilanto Ramamonjisoa, Ellen Ackerstaff
Jul 20, 2014·Cancer Immunology Research·Tsvetelina Pentcheva-HoangJames P Allison
Apr 30, 2014·Cancer Immunology Research·Matthew Tontonoz, Connie E Gee

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