Intravital microscopy in window chambers: a unique tool to study tumor angiogenesis and delivery of nanoparticles

Angiogenesis
Sjoerd HakCatharina de Lange Davies

Abstract

Solid tumor growth is heavily dependant on angiogenesis. Tumor angiogenesis is the result of a complex interplay between tumor cells, endothelial cells, and other stromal cells. It has been found to be under strict control of a plethora of molecular factors that function as angiogenic up- and down-regulators; nevertheless, the identification of molecular and cellular players and their roles in angiogenesis is still ongoing. The microvasculature resulting from tumor angiogenesis lacks hierarchy and has a high permeability for macromolecules and nanoparticles, which offers significant potential for nanoparticulate tumor imaging and drug delivery platforms. However, improvements in the delivery to poorly vascularized regions and the distribution throughout the tumor interstitium are critical for nanoparticles to become more effective in the battle against cancer. A tool that has proven extremely valuable in both unraveling angiogenic pathways and characterizing in vivo nanoparticle behavior in solid tumors is intravital microscopy of tumors grown in window chamber preparations. In this review this technique is explained, several exciting examples illustrating its value in elucidating tumor angiogenesis are presented and the study ...Continue Reading

References

Nov 1, 1979·Microvascular Research·H D PapenfussF A Treese
Sep 30, 1991·Biochimica Et Biophysica Acta·T M Allen, C Hansen
Jan 1, 1987·Cancer Metastasis Reviews·R K Jain
Jan 1, 1973·Microvascular Research·J C Nims, J W Irwin
Nov 18, 1971·The New England Journal of Medicine·J Folkman
Mar 1, 1972·Annals of Surgery·J Folkman
Oct 1, 1970·Microvascular Research·K E ArforsF N McKenzie
Jun 1, 1967·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D M Goldenberg, S Witte
Mar 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·I P Torres FilhoR K Jain
Dec 1, 1996·International Journal of Radiation Oncology, Biology, Physics·M H GaberD Papahadjopoulos
Mar 1, 1997·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·J R LessR K Jain
Mar 1, 1997·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·N Z WuM W Dewhirst
Apr 29, 1998·The Journal of Clinical Investigation·G ThurstonD M McDonald
May 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·S K HobbsR K Jain
Sep 2, 1998·Proceedings of the National Academy of Sciences of the United States of America·R K JainE Keshet
Dec 19, 1998·The Journal of the Acoustical Society of America·G M LanzaS A Wickline
Jan 20, 2000·Journal of the National Cancer Institute·C Y LiM W Dewhirst
May 2, 2000·British Journal of Cancer·M DellianR K Jain
Aug 10, 2000·Neoplasia : an International Journal for Oncology Research·R J GilliesN Raghunand
Feb 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·M YangR M Hoffman
Mar 22, 2001·Advanced Drug Delivery Reviews·R K Jain
Mar 29, 2001·Proceedings of the National Academy of Sciences of the United States of America·A PluenR K Jain
Jul 17, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G N HortobagyiM C Hung
Aug 8, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·D E MeyerA Chilkoti
Feb 16, 2002·Biochemical and Biophysical Research Communications·Mathias Lundberg, Magnus Johansson
Mar 22, 2002·Nature·Yotaro IzumiRakesh K Jain
May 11, 2002·Nature Reviews. Cancer·Rakesh K JainDai Fukumura
Apr 25, 2003·International Journal of Cancer. Journal International Du Cancer·Senat KrasniciMarc Dellian
May 31, 2003·Science·Daniel R LarsonWatt W Webb
Aug 23, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Raymond M SchiffelersGert Storm
Oct 7, 2003·Annual Review of Biomedical Engineering·Jennifer L West, Naomi J Halas
Mar 26, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lars H LindnerMarc Dellian
Apr 1, 2004·International Journal of Cancer. Journal International Du Cancer·Sebastian StriethMarc Dellian

❮ Previous
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Citations

Jun 19, 2010·Angiogenesis·Willem J M Mulder, Arjan W Griffioen
May 2, 2013·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Antje DietrichLeoni A Kunz-Schughart
Aug 1, 2012·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Gus A WrightChristopher Janetopoulos
Apr 6, 2012·Nature Reviews. Cancer·Benjamin J VakocBrett E Bouma
Jun 20, 2013·The Journal of Clinical Investigation·Stephen W JonesJames E Bear
Sep 18, 2012·Current Opinion in Pharmacology·Felicity N E Gavins
Mar 8, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Takahiro NomotoKazunori Kataoka
Oct 12, 2010·Advanced Drug Delivery Reviews·Panomwat AmornphimolthamRoberto Weigert
Feb 19, 2011·Thrombosis and Haemostasis·L Zagorchev, M J Mulligan-Kehoe
Apr 15, 2014·Contrast Media & Molecular Imaging·Xiao-Guang YouLi-Jun Wen
May 23, 2012·Journal of Biomedical Optics·Jan LauferPaul Beard
May 24, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Siv EggenCatharina de Lange Davies
Jul 31, 2013·Current Opinion in Cell Biology·Stephanie AlexanderPeter Friedl
Aug 5, 2014·Trends in Biotechnology·Sabine Hauert, Sangeeta N Bhatia
Jun 22, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Redouane BouchaalaAndrey S Klymchenko
Jan 4, 2017·Chemical Reviews·Bryan Ronain Smith, Sanjiv Sam Gambhir
Oct 28, 2019·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Alexandros Marios SofiasSjoerd Hak
Jun 4, 2017·Journal of Controlled Release : Official Journal of the Controlled Release Society·Vaidotas KiseliovasArturas Ziemys
Oct 31, 2018·Molecular Pharmaceutics·Alexandros Marios SofiasSjoerd Hak

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