Intravital microscopy reveals endothelial dysfunction in resistance arterioles in Angiotensin II-induced hypertension

Hypertension Research : Official Journal of the Japanese Society of Hypertension
Stephan C SchäferLucia Mazzolai

Abstract

It is known that hypertension is associated with endothelial dysfunction and that Angiotensin II (Ang II) is a key player in the pathogenesis of hypertension. We aimed to elucidate whether endothelial dysfunction is a specific feature of Ang II-mediated hypertension or a common finding of hypertension, independently of underlying etiology. We studied endothelial-dependent vasorelaxation in precapillary resistance arterioles and in various large-caliber conductance arteries in wild-type mice with Ang II-dependent hypertension (2-kidney 1-clip (2K1C) model) or Ang II-independent (volume overload) hypertension (1-kidney 1-clip model (1K1C)). Normotensive sham mice were used as controls. Aortic mechanical properties were also evaluated. Intravital microscopy of precapillary arterioles revealed a significantly impaired endothelium-dependent vasorelaxation in 2K1C mice compared with sham mice, as quantified by the ratio of acetylcholine (ACh)-induced over S-nitroso-N-acetyl-D,L-penicillamine (SNAP)-induced vasorelaxation (2K1C: 0.49±0.12 vs. sham: 0.87±0.11, P=0.018). In contrast, the ACh/SNAP ratio in volume-overload hypertension 1K1C mice was not significantly different from sham mice, indicating no specific endothelial dysfunction...Continue Reading

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Citations

Feb 13, 2013·Neurotoxicity Research·Mak Adam Daulatzai
Nov 6, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jeong-Yong ChoKyung-Sik Ham
Feb 26, 2016·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Pavel SvitokMichal Zeman
Feb 26, 2015·Hypertension·Loïc Le GalJacques-Antoine Haefliger
Feb 11, 2016·Molecular Medicine Reports·Miao-Qian ShiZhi-Chun Feng
Dec 20, 2016·Journal of Thrombosis and Haemostasis : JTH·J D WelshL F Brass
Nov 13, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jeong-Yong ChoKyung-Sik Ham

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