Intravitreal aflibercept for diabetic macular oedema: Moorfields' real-world 12-month visual acuity and anatomical outcomes.

European Journal of Ophthalmology
Marko LukicRanjan Rajendram

Abstract

To assess structural and functional outcomes of treatment with intravitreal aflibercept (Eylea®) for diabetic macular oedema in treatment-naive patients. This is a retrospective, real-life, cohort study. In all, 92 diabetic patients (102 eyes) receiving intravitreal anti-vascular endothelial growth factor therapy were included. A total of 99 aflibercept-treated eyes were included in the statistical analysis. Each patient had corrected visual acuity in Early Treatment Diabetic Retinopathy Study letters and optical coherence tomography central foveal thickness and macular volume performed at baseline and 12 months. Patients were initiated on a loading phase of five monthly intravitreal aflibercept injections, followed by injections if needed as per clinicians' discretion. The mean number of aflibercept injections received was 6.92. At baseline, the mean visual acuity (standard deviation; Snellen) was 59.7 (16.1) (20/63) Early Treatment Diabetic Retinopathy Study letters, the mean central foveal thickness (standard deviation) was 431 (129) µm, while the mean macular volume (standard deviation) was 9.53 (1.79) mm3. At 12 months, the mean visual acuity (standard deviation; Snellen) was 69.6 (15.2; 20/40) Early Treatment Diabetic Ret...Continue Reading

References

Apr 30, 2010·Ophthalmology·UNKNOWN Diabetic Retinopathy Clinical Research NetworkJennifer K Sun
Feb 4, 2012·Diabetes Care·Joanne W Y YauUNKNOWN Meta-Analysis for Eye Disease (META-EYE) Study Group
Feb 15, 2012·Ophthalmology·Quan Dong NguyenUNKNOWN RISE and RIDE Research Group
Apr 28, 2012·Ophthalmology·Diana V DoUNKNOWN da Vinci Study Group
Jul 12, 2014·Ophthalmology·Jean-François KorobelnikDavid M Brown
Feb 19, 2015·The New England Journal of Medicine·UNKNOWN Diabetic Retinopathy Clinical Research NetworkRoy W Beck
Jan 24, 2016·American Journal of Ophthalmology·Susan B BresslerUNKNOWN Diabetic Retinopathy Clinical Research Network
Sep 18, 2016·American Journal of Ophthalmology·Namritha V PatraoUNKNOWN Moorfields Diabetic Macular Edema Study Group

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Citations

Jan 3, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Jean-François KorobelnikPascale Massin
Jun 14, 2021·Ophthalmology and Therapy·Rodrigo AnguitaPraveen J Patel

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