Intravitreal Aflibercept Injection in Patients with Myopic Choroidal Neovascularization: The MYRROR Study

Ophthalmology
Yasushi IkunoMYRROR Investigators

Abstract

To evaluate intravitreal aflibercept 2 mg in patients with myopic choroidal neovascularization (CNV). An international, phase III, multicenter, randomized, double-masked, sham-controlled study. Patients aged ≥ 18 years with high myopia (≤-6.0 diopters or axial length of ≥ 26.5 mm), active myopic CNV, and best-corrected visual acuity (BCVA) of 73-35 Early Treatment Diabetic Retinopathy Study letters in the study eye were included. Patients were randomized 3:1 to intravitreal aflibercept or sham. In the intravitreal aflibercept arm, patients received 1 injection at baseline. Additional injections were performed in case of CNV persistence or recurrence at monthly visits through week 44. In the sham arm, patients received sham injections through week 20. At week 24, after assessment of the primary efficacy end point, sham patients received a mandatory intravitreal aflibercept injection followed by intravitreal aflibercept (if disease persisted/recurred) or sham injection every 4 weeks. Mean change in BCVA from baseline to week 24. A total of 122 patients were randomized to intravitreal aflibercept (n = 91) or sham (n = 31). Baseline demographics were similar across groups. At week 24, patients in the intravitreal aflibercept and sh...Continue Reading

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