Intravitreal Anti-Vascular Endothelial Growth Factor Treatment for Pachychoroid Neovasculopathy

Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics
Han Joo ChoJong Woo Kim

Abstract

To compare the effectiveness of intravitreal anti-vascular endothelial growth factor (anti-VEGF) treatment for pachychoroid neovasculopathy and neovascular age-related macular degeneration (AMD). Twenty-two eyes with pachychoroid neovasculopathy and 183 eyes with neovascular AMD were retrospectively included for analysis. All patients were treatment naive and received an initial series of 3 monthly loading injections of anti-VEGF, followed by further injections as required. The visual and anatomical outcomes after treatment were evaluated at 12 months from baseline. The pachychoroid neovasculopathy group showed a significant improvement in the mean best-corrected visual acuity (BCVA; logarithm of the minimum angle of resolution) from 0.50 ± 0.32 (Snellen equivalent; 20/63) to 0.31 ± 0.28 (20/85, P = 0.021), and a decrease in the mean central foveal thickness from 373 ± 184 μm to 195 ± 137 μm at 12 months (P < 0.001). No significant intergroup difference in the achieved improvement of BCVA and decrease of central foveal thickness was observed. However, compared with the neovascular AMD group, the pachychoroid neovasculopathy group showed lower proportions of patients requiring retreatment during the maintenance phase (59.1% vs. ...Continue Reading

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Citations

Apr 3, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Yoko KitajimaKazuaki Kadonosono
Apr 23, 2020·Japanese Journal of Ophthalmology·Yasuo Yanagi
Mar 1, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Benedikt SchwormJakob Siedlecki
Nov 25, 2020·Ophthalmic Surgery, Lasers & Imaging Retina·Özlem BiçerEmin Özmert
Dec 2, 2020·Acta Ophthalmologica·Shyamanga BorooahDhiren Bujarborua
Dec 8, 2019·Ophthalmology Retina·Jakob SiedleckiSiegfried G Priglinger
Jun 3, 2021·Journal of Clinical Medicine·Koji TanakaHiroyuki Nakashizuka
Jul 31, 2021·European Journal of Ophthalmology·Pradeep SagarShorya Vardhan Azad

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