Intravitreal bevacizumab and triamcinolone acetonide combination therapy for exudative neovascular age-related macular degeneration: short-term optical coherence tomography results

Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics
Michael Colucciello

Abstract

The aim of this study to describe the short-term anatomical results after an intravitreal injection of bevacizumab and triamcinolone acetonide in patients with foveal edema and/or subfoveal fluid associated with neovascularization (NV) due to age-related macular degeneration (AMD). A retrospective, noncomparative case series was conducted in patients with foveal edema and/or subfoveal fluid associated with NV due to AMD during a 3-month period. Patients were treated with intravitreal injections of bevacizumab (1.25 mg/0.05 mL) and followed immediately with triamcinolone acetonide (2 mg/ 0.05 mL) in separate syringes. Ophthalmoscopic examination with optical coherence tomography analysis of foveal edema and subfoveal fluid volume was performed at baseline and follow-up visits. There were 30 consecutive eyes of 27 patients who received a short-term follow-up between 1 and 8 weeks after injection. Foveal thickness and subfoveal fluid volume were each statistically significantly reduced in the short term (paired Student t test; P < 0.01). No complications of intraocular pressure greater than 30 mmHg, endophthalmitis, retinal detachment, or vitreous hemorrhage developed. Reduction of foveal edema and subfoveal fluid in patients with...Continue Reading

References

Jun 1, 1994·Archives of Ophthalmology·K Dastgheib, W R Green
Feb 1, 1997·Endocrine Reviews·N Ferrara, T Davis-Smyth
Dec 8, 1998·Australian and New Zealand Journal of Ophthalmology·J K ChallaF A Billson
Nov 1, 1995·Australian and New Zealand Journal of Ophthalmology·P L PenfoldF A Billson
Mar 12, 2004·American Journal of Ophthalmology·Ronald KleinMylan R Vannewkirk
Oct 16, 2004·Retina·Lloyd P AielloMichael T Trese
Dec 31, 2004·The New England Journal of Medicine·Evangelos S GragoudasUNKNOWN VEGF Inhibition Study in Ocular Neovascularization Clinical Trial Group
Oct 13, 2005·Archives of Ophthalmology·Ute E K SchnurrbuschSebastian Wolf
Feb 3, 2006·Proceedings of the National Academy of Sciences of the United States of America·Miho NozakiJayakrishna Ambati
Feb 7, 2006·Ophthalmology·Robert L AveryMatthew J Giust
Jun 2, 2006·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Hiroyuki ShimadaMitsuko Yuzawa
Jul 4, 2006·American Journal of Ophthalmology·Ziad F BashshurBaha' N Noureddin
Oct 6, 2006·The New England Journal of Medicine·Philip J RosenfeldUNKNOWN MARINA Study Group
Oct 6, 2006·The New England Journal of Medicine·David M BrownUNKNOWN ANCHOR Study Group
Jul 3, 2007·American Journal of Ophthalmology·Mark C Gillies, Jorgen Larsson
Aug 29, 2007·Investigative Ophthalmology & Visual Science·Margrit HollbornAndreas Bringmann

❮ Previous
Next ❯

Citations

Feb 3, 2009·Pharmaceutical Research·Saffar MansoorM Cristina Kenney
Apr 27, 2010·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Yong Tao, Jost B Jonas
Dec 12, 2012·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Daniele VerittiPaolo Lanzetta
Dec 22, 2010·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Marieke VeurinkRobert Gurny
Mar 11, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kohei HironakaHirofumi Takeuchi
Feb 23, 2013·Current Opinion in Ophthalmology·Miriam Englander, Peter K Kaiser
Mar 6, 2019·The Cochrane Database of Systematic Reviews·Sharon D SolomonBarbara S Hawkins
Jan 31, 2009·Postgraduate Medicine·Daniel Kravitz, Ray F Gariano

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.