Intravitreal bevacizumab for treatment-naive patients with subfoveal occult choroidal neovascularization secondary to age-related macular degeneration: a 12-month follow-up study

Retina
Ciro CostagliolaFrancesco Parmeggiani

Abstract

The aim of this study was to assess the 12-month efficacy of intravitreal bevacizumab (IVB) injection for occult choroidal neovascularization secondary to age-related macular degeneration. In this retrospective, interventional case series, 68 treatment-naïve patients with age-related macular degeneration, affected by subfoveal occult choroidal neovascularization showing recent disease progression, were monitored during the IVB protocol. The patients received 1 initial IVB injection (1.25 mg/0.05 mL), and they underwent further retreatment on a monthly basis only when necessary, according to a standardized as-required regimen, until no significant signs of choroidal neovascularization activity were present. Main outcome measures were the modifications in best-corrected visual acuity and in central retinal thickness measured by optical coherence tomography. With respect to baseline, at the 12-month check, mean best-corrected visual acuity increased from 0.82 to 0.45 logMAR (P < 0.01) and mean central retinal thickness decreased from 517.0 microm to 306.5 microm (P < 0.01). To achieve these benefits, the required mean IVB number was lowered from 3.87 in the first 6 months to 1.085 in the second 6 months. A better final best-correc...Continue Reading

References

Mar 24, 2005·JAMA : the Journal of the American Medical Association·Peter van WijngaardenKeryn A Williams
Dec 6, 2005·Ophthalmology·Ursula Schmidt-ErfurthStephan Michels
Feb 7, 2006·Ophthalmology·Robert L AveryMatthew J Giust
Jul 4, 2006·American Journal of Ophthalmology·Ziad F BashshurBaha' N Noureddin
Aug 25, 2006·The British Journal of Ophthalmology·U ChakravarthyS Wolf
Oct 6, 2006·The New England Journal of Medicine·Philip J RosenfeldUNKNOWN MARINA Study Group
Nov 1, 2006·Progress in Retinal and Eye Research·Sarah X Zhang, Jian-xing Ma
Nov 18, 2006·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Ratimir Lazic, Nikica Gabric
Dec 23, 2006·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·S AisenbreyK U Bartz-Schmidt
Mar 8, 2007·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Ivan Goldberg, Robert Ritch
Apr 14, 2007·The British Journal of Ophthalmology·James RafteryAndrew Lotery
Aug 4, 2007·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Lihteh WuUNKNOWN Pan American Collaborative Retina Group (PACORES)
Apr 2, 2008·Investigative Ophthalmology & Visual Science·Francesco ParmeggianiCarlo Incorvaia
May 9, 2008·Retina·Claudio CampaCarlo Incorvaia

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Citations

Aug 31, 2013·Drug Design, Development and Therapy·F SemeraroC Costagliola
Oct 16, 2010·Acta Ophthalmologica·Raimondo ForteGiovanni Cennamo
May 26, 2011·Seminars in Ophthalmology·Georges M El-MollayessZiad F Bashshur
Sep 15, 2011·Molecular Diagnosis & Therapy·Francesco ParmeggianiCarlo Incorvaia

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