Intravitreal bevacizumab for treatment of choroidal neovascularization associated with osteogenesis imperfecta.

Indian Journal of Ophthalmology
Pukhraj RishiAnusha Venkatraman

Abstract

A 12-year-old girl, diagnosed of osteogenesis imperfecta, presented with sudden visual loss in the left eye. Investigations revealed an active choroidal neovascular membrane. She underwent treatment with intravitreal Bevacizumab (1.25 mg/0.05 ml). Follow-up at 1 month revealed the development of lacquer crack running through the macula, underlying the fovea. The patient received two re-treatments at 1-month intervals, following which the choroidal neovascularization (CNV) regressed completely. However, further progression of lacquer cracks was noted. At the last follow-up, 6 months following the last injection, the fundus remained stable and vision was maintained at 20/200. Considering the natural history of the disease and the increased risk of rupture of the Bruch's membrane in such eyes, the possible complication of a lacquer crack developing must be borne in mind, before initiating treatment.

References

Aug 1, 1993·The British Journal of Ophthalmology·G E MarshallW R Lee
Dec 13, 2002·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Cem EverekliogluNecdet A Bekir
Jul 16, 2003·Archives of Ophthalmology·Dean EliottJohn Lewis
Dec 7, 2006·International Ophthalmology·Andrew ScottHamish M A Towler
Oct 6, 2009·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Pratik Ranjan SenDaraius Shroff

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Citations

Nov 13, 2015·Orphanet Journal of Rare Diseases·Louise F PorterGraeme C Black
Feb 24, 2016·Clinics in Dermatology·Melinda Jen, Sudha Nallasamy
Feb 14, 2019·European Journal of Ophthalmology·Peter J BelinRonni M Lieberman
May 20, 2021·Acta Ophthalmologica·Sanne TreurnietElisabeth Marelise W Eekhoff

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