Intravitreal chemotherapy for the treatment of recurrent intraocular lymphoma

The British Journal of Ophthalmology
Marc D De SmetC C Chan

Abstract

To develop and assess a protocol for the treatment of intraocular lymphoma by intravitreal injection of methotrexate and thiotepa. A patient with intraocular non-Hodgkin's lymphoma which recurred after radiotherapy and repeated systemic chemotherapeutic regimens underwent repeated intravitreal injections of methotrexate and thiotepa. The patient was closely monitored by cytology, anterior chamber flare measurements, IL-10 and IL-6 levels. Methotrexate drug clearance studies were performed on vitreous samples taken before each injection. Complete tumour clearance was achieved by the third week of therapy. IL-10 and IL-6 levels quickly dropped to barely detectable levels as the tumour was cleared from the eye. Flare measurements decreased from 500 to 15 photons/s over the same time. A plot of the methotrexate levels over time revealed a first order kinetic rate of elimination with an effective tumoricidal intravitreal dose persisting for 5 days after injection. Intravitreal chemotherapy for the treatment of recurrent intraocular lymphoma appears effective in prolonging local remission of ocular disease even in the presence of an aggressively growing tumour. A single intravitreal injection of methotrexate can lead to a prolonged t...Continue Reading

References

Jul 24, 1975·The New England Journal of Medicine·W R ShapiroB M Mehta
Sep 1, 1976·Radiology·R C Chan, L J Shukovsky
Mar 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·F RoussetJ Banchereau
Oct 1, 1991·The British Journal of Ophthalmology·M ViebahnM D Osterloh
Oct 1, 1990·Archives of Neurology·M C Chamberlain, V A Levin
Apr 1, 1986·Cancer·M A BaumannT Anderson
Jan 1, 1989·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·A J RouwenJ S Stilma
Dec 1, 1982·Ophthalmology·G C BrownN J Schatz
Dec 1, 1982·Ophthalmology·G C BrownN J Schatz
Feb 1, 1995·The British Journal of Ophthalmology·S SeregardE af Trampe
Jan 1, 1993·Clinical Oncology : a Journal of the Royal College of Radiologists·P Nicholas PlowmanS Lightman
Aug 1, 1993·Cancer·K PetersonLisa M Deangelis
Jul 1, 1995·Survey of Ophthalmology·M A De La Paz, M Boniuk
Sep 23, 1997·Archives of Ophthalmology·B C FishburneEdward A Neuwelt

Citations

Jul 15, 2011·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Maher SalehDavid Gaucher
Oct 3, 2006·Japanese Journal of Ophthalmology·Jia-Kang WangHwei-Fang Tien
Jul 29, 2008·Japanese Journal of Ophthalmology·Reika SouYasuo Tano
Aug 5, 2004·Current Oncology Reports·Igor T Gavrilovic, Lauren E Abrey
Dec 22, 2004·Current Oncology Reports·Igor T Gavrilovic, Lauren E Abrey
Dec 22, 2004·Current Oncology Reports·Stella K KimDana J Wallace
Mar 29, 2001·Survey of Ophthalmology·M W WilsonB G Haik
Mar 29, 2002·Survey of Ophthalmology·Russell W ReadNarsing A Rao
Feb 18, 2011·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Nikhil Kumar PalakurthiRupak K Banerjee
Apr 18, 2001·Current Opinion in Oncology·Ronald R BuggageRobert B Nussenblatt
Mar 10, 2005·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Daniel K FahimMark W Johnson
Nov 21, 2002·Current Opinion in Ophthalmology·Chi-Chao ChanRobert B Nussenblatt
Sep 10, 2008·Retina·Paul W HardwigSophie J Bakri
Jul 9, 2009·Retina·Gholam A PeymanDarius M Moshfeghi
Feb 22, 2011·Retina·Rithwick Rajagopal, J William Harbour
Jul 27, 2011·Therapeutic Advances in Medical Oncology·Nooshin Hashemi-Sadraei, David M Peereboom
May 19, 2011·Indian Journal of Ophthalmology·Ebru B OzkanNazan Alparslan
Feb 20, 2014·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Noriyasu HashidaKohji Nishida
Feb 1, 2014·Journal of the American Veterinary Medical Association·K Tomo WiggansDavid J Maggs
Jan 27, 2004·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Eric Tourville, Yvon Tardif
Oct 12, 2013·Survey of Ophthalmology·Bruno F FernandesMiguel N Burnier
Jul 3, 2003·Clinical Lymphoma·Adília Hormigo, Lisa M Deangelis
Jan 18, 2006·Survey of Ophthalmology·Dana J WallaceChi-Chao Chan
Oct 22, 2004·Seminars in Oncology·Lisa M Deangelis, Adília Hormigo
Oct 22, 2010·Current Eye Research·Nikhil Kumar PalakurthiRupak K Banerjee
May 21, 2010·Ocular Immunology and Inflammation·Sanjeewa S WickremasingheEhud Zamir
Apr 22, 2015·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Soumyarwit MannaZelia M Correa
Jan 1, 2012·Translational Vision Science & Technology·Noriyasu HashidaKohji Nishida
Feb 25, 2014·Survey of Ophthalmology·Mandeep S SagooSue Lightman
May 1, 2010·Expert Opinion on Pharmacotherapy·Matteo G CarrabbaAndrés J M Ferreri
Feb 8, 2014·Korean Journal of Ophthalmology : KJO·Choul Yong ParkJong-Hyun Oh
Oct 13, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K JahnkeA Korfel
Sep 14, 2007·Current Eye Research·Juyoung ParkRupak K Banerjee
Jan 5, 2002·Expert Opinion on Pharmacotherapy·Deric Minwoo Park, Lauren E Abrey
Sep 14, 2007·Current Eye Research·Esther Eljarrat-BinstockJacob Pe'er
Dec 17, 2009·Ocular Immunology and Inflammation·Chi-Chao ChanBahram Bodaghi
Jun 3, 2020·Ophthalmic Surgery, Lasers & Imaging Retina·Joseph M SimonettPhoebe Lin
Feb 10, 2016·Current Opinion in Ophthalmology·David Reichstein
Oct 17, 2009·Ocular Immunology and Inflammation·Jacob Pe'erC Stephen Foster
Jul 17, 2017·International Ophthalmology·Ozge Yabas KizilogluOkan Toygar
Sep 21, 2004·Cancer Control : Journal of the Moffitt Cancer Center·Chi-Chao Chan, Dana J Wallace
Aug 28, 2020·Journal of Ophthalmology·Ge Wang, Xiaoyan Peng
May 25, 2016·Cancer Control : Journal of the Moffitt Cancer Center·Matthew T Witmer
Oct 23, 2020·The British Journal of Ophthalmology·Mona MohammadMandeep S Sagoo

Related Concepts

Antineoplastic Chemotherapy Protocols
Cytonal
Malignant Tumor of Eye
Injectables
Methotrexate, (DL)-Isomer
Neoplasm Recurrence, Local
Interleukin-6
Diffuse Large B-Cell Lymphoma
Interleukin-10

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