Intravitreal dexamethasone for diabetic macular edema: a pilot study

Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye
Carmen K M ChanDennis S C Lam

Abstract

To determine the response and safety profile of intravitreal dexamethasone in treating diabetic macular edema. In this prospective pilot study, 12 eyes of 12 patients with diabetic macular edema were randomized to receive a single injection of 0.4 mg (n = 6) or 0.8 mg (n = 6) of intravitreal dexamethasone. The outcome measures were changes in best-corrected visual acuity and central foveal thickness on optical coherence tomography. Side effects were monitored. The 3-month results were reported. In both dosage groups, there were transient improvements in best-corrected visual acuity and central foveal thickness, but the changes were not significant at any time point (best-corrected visual acuity: P > or = 0.14; central foveal thickness: P > or = .08). No significant side effects were observed, except one eye developed a peak intraocular pressure of greater than 21 mm Hg. A single injection of intravitreal dexamethasone (0.4 or 0.8 mg) did not have significant beneficial effects on diabetic macular edema within 3 months from injection in this small pilot study.

References

Oct 18, 2005·American Journal of Ophthalmology·Teresio AvitabileAlfredo Reibaldi
Oct 20, 2005·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Ivan M GanJan C van Meurs
Nov 16, 2005·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Hamdi Er, Harun Yilmaz
Sep 16, 2006·The British Journal of Ophthalmology·Dennis S C LamMahesh P Shanmugam
Mar 14, 2007·Archives of Ophthalmology·Baruch D KuppermannUNKNOWN Dexamethasone DDS Phase II Study Group
Jan 1, 2008·Global Public Health·K R Camarg, R A Mattos

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Citations

Nov 14, 2013·Current Ophthalmology Reports·Stephen G SchwartzIngrid U Scott
Jun 19, 2013·Survey of Ophthalmology·Weerawat KiddeeYvonne M Buys
Apr 22, 2011·Ophthalmology·William E Smiddy
Apr 1, 2011·Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society·Abdulrahman A Alghadyan

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