Intravitreal Injections of Voriconazole for Candida Endophthalmitis: A Case Series

Ocular Immunology and Inflammation
Anne-Lise BienvenuLaurent Kodjikian

Abstract

Candida endophthalmitis represents a therapeutic challenge, considering the inability of many antifungals to achieve adequate concentrations in the vitreous. Intravitreal injection (IVI) of antifungals (amphotericin b deoxycholate or voriconazole) is therefore recommended. Whereas amphotericin b IVI is well documented, clinical data on voriconazole IVI are limited. This was a retrospective review IRB approved of patients receiving voriconazole IVI for Candida endophthalmitis. Complete ophthalmological examination was completed at baseline and during follow-up. Five patients were treated with a mean four injections [range: 2-9] of voriconazole (100 µg/0.1 mL saline). Improvement of visual acuity and disappearance of signs of infection were obtained in all patients. Safety concern including photoreceptor toxicity was not attributed to voriconazole IVI. Voriconazole IVI demonstrated to be safe and led to a favorable clinical outcome. Thus, voriconazole IVI must be performed if Candida endophthalmitis is suspected to increase the chance of clinical success.

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Citations

Nov 6, 2020·Journal of Ophthalmology·Ciprian DanielescuMihnea Munteanu
Jun 20, 2020·Archivos de la Sociedad Española de Oftalmología·M García RoaP Ramírez Neria
Dec 20, 2021·Therapeutic Drug Monitoring·Benjamin KablyEliane M Billaud

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