Intravitreal invasion of malignant cells from choroidal melanoma after brachytherapy

Archives of Ophthalmology
D M Robertson, R J Campbell

Abstract

We report intravitreal invasion by melanoma cells from a choroidal melanoma after brachytherapy. A malignant melanoma of the choroid with collar-button configuration was treated with iodine 125 brachytherapy. Years later, the collar button developed a dark-chocolate color and began shedding pigmented debris into the vitreous. Coalescence of this debris into spheroidal aggregates suggested the presence of malignant cells; the eye was enucleated. Histologic sections demonstrated a choroidal melanoma with intraretinal and intravitreal invasion by melanoma. Clinical evidence of intraretinal invasion by melanoma cells along with pigmented debris within the vitreous cavity, especially when clustered in spheroidal aggregates, suggests the presence of intravitreal invasion by malignant cells. In this case, intravitreal invasion was verified histologically.

Citations

Sep 12, 2015·The British Journal of Ophthalmology·Claudia H D MetzMete Gök
Aug 23, 2002·Acta Ophthalmologica Scandinavica·Hayyam Kiratli, Sevgül Bilgiç
Oct 8, 2019·Ophthalmic Surgery, Lasers & Imaging Retina·Manuel Paez-EscamillaJ William Harbour
Nov 17, 2017·International Journal of Retina and Vitreous·Andre A C VidorisRubens N Belfort
Jul 27, 2018·Retinal Cases & Brief Reports·Babak MasoomianCarol L Shields
Oct 4, 2020·Retina·Vishal RavalArun Singh
Nov 15, 2002·Survey of Ophthalmology·Dennis M Robertson
Aug 14, 2019·Retinal Cases & Brief Reports·Arman MashayekhiJerry A Shields

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