Intravitreal steroids for macular edema in diabetes.

The Cochrane Database of Systematic Reviews
Thanitsara RittiphairojGianni Virgili

Abstract

Diabetic macular edema (DME) is secondary to leakage from diseased retinal capillaries with thickening of central retina, and is an important cause of poor central visual acuity in people with diabetic retinopathy. Intravitreal steroids have been used to reduce retinal thickness and improve vision in people with DME. To assess the effectiveness and safety of intravitreal steroid therapy compared with other treatments for DME. We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, and Embase on 15 May, 2019. We also searched reference lists, Science Citation Index, conference proceedings, and relevant trial registers. We conducted a top up search on 21 October, 2020. We included randomized controlled trials that evaluated any type of intravitreal steroids as monotherapy against any other intervention (e.g. observation, laser photocoagulation, anti-vascular endothelial growth factor (antiVEGF) for DME. Two review authors independently assessed study eligibility and risk of bias and extracted data. Where appropriate, we performed meta-analyses. We included 10 trials (4348 participants, 4505 eyes). These trials compared intravitreal steroid therapies versus other treatments, including intravitreal antiVE...Continue Reading

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