PMID: 9442778Jan 27, 1998Paper

Intravitreal sustained-release cyclosporine in the treatment of experimental uveitis

Ophthalmology
Glenn J JaffePaul Ashton

Abstract

Uveitis often is a chronic disease requiring long-term medical therapy. Despite treatment, the disease may be difficult to control and may produce serious, vision-threatening ocular complications. In this study, the authors determined whether an intravitreal cyclosporine-sustained delivery device was effective in the treatment of ocular inflammation in a rabbit model of uveitis. New Zealand White rabbits were immunized subcutaneously with Mycobacterium tuberculosis H37Ra antigen. Fourteen days later, sustained-release cyclosporine devices were implanted into the vitreous cavity of the right eye of experimental rabbits. Control animals received sham devices. Seven days after device implantation, rabbits were challenged with an intravitreal injection of tuberculin antigen. To simulate chronic inflammation with exacerbations, some animals were rechallenged with intravitreal antigen on day 21 after device implantation. Inflammation was assessed clinically by a masked observer who graded anterior chamber cells, flare, corneal neovascularization, iris congestion, and vitreous opacity daily until day 7 and on day 13 after the initial intravitreous challenge, and on days 1 and 2 after the rechallenge. Retinal function was evaluated by ...Continue Reading

References

Sep 1, 1979·European Journal of Immunology·A A AugustinH Cosenza
Jun 1, 1990·The British Journal of Ophthalmology·D BenEzraP Timonen
Oct 1, 1985·Archives of Ophthalmology·R B NussenblattA G Palestine
Sep 1, 1994·The Journal of Experimental Medicine·D UnutmazS Abrignani
Jan 1, 1993·International Ophthalmology Clinics·M D de Smet, R B Nussenblatt
Mar 1, 1996·Archives of Ophthalmology·P A PearsonP Ashton
Jan 1, 1996·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·D P HainsworthP Ashton

❮ Previous
Next ❯

Citations

Feb 13, 2002·Arthritis and Rheumatism·Justine R Smith, James T Rosenbaum
Sep 16, 2005·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Xiaoguang DongPing Lin
Aug 25, 2004·Survey of Ophthalmology·Paris G TranosCarlos E Pavesio
Oct 25, 2000·Veterinary Immunology and Immunopathology·B C GilgerJ B Allen
Nov 7, 2003·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·F LallemandR Gurny
Oct 6, 2001·Progress in Retinal and Eye Research·M D de Smet, C C Chan
Jun 14, 2002·Progress in Retinal and Eye Research·Jayakrishna Ambati, Anthony P Adamis
Sep 25, 2002·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Randal T H PhamMichael F Marmor
May 26, 2006·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Yuan HeQiang Zhang
May 22, 2009·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Jae Pil ShinSi Yeol Kim
May 3, 2000·International Ophthalmology Clinics·C L Haupert, G J Jaffe
Oct 27, 1999·The British Journal of Ophthalmology·G Velez, S M Whitcup
Jul 26, 2002·The British Journal of Ophthalmology·S KunimatsuM Araie
Feb 25, 2000·BMJ : British Medical Journal·P J McCluskeyS Lightman
Mar 30, 2005·Journal of Biomaterials Science. Polymer Edition·Hai-Quan MaoKam W Leong
Nov 24, 2007·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·J R Smith, J T Rosenbaum
Aug 24, 1999·Springer Seminars in Immunopathology·R N Van Gelder, H J Kaplan
May 24, 2012·TheScientificWorldJournal·Burçin YavuzNurşen Unlü
Nov 7, 2009·Journal of Pharmaceutical Sciences·Yahya E ChoonaraLisa C du Toit
Oct 16, 2015·International Ophthalmology·Mohammed ZiaeiBita Manzouri
Jan 8, 2013·International Journal of Pharmaceutics·Simone EperonYan Guex-Crosier
Nov 17, 2006·Advanced Drug Delivery Reviews·J L BourgesF Behar-Cohen
May 19, 2005·Journal of Biomedical Materials Research. Part a·Nathan R F BeeleySigne E Varner
Nov 23, 2005·Journal of Biomedical Materials Research. Part a·Nathan R F BeeleySigne E Varner
Aug 9, 2007·Expert Opinion on Drug Delivery·Kumar G JanoriaAshim K Mitra
Mar 2, 2006·Expert Opinion on Drug Delivery·Tsutomu YasukawaYasuhiko Tabata
Mar 2, 2006·Expert Opinion on Drug Delivery·Deepta Ghate, Henry F Edelhauser
Jan 5, 2002·Expert Opinion on Investigational Drugs·Susan Lightman, Howesen Kok
Aug 3, 2011·Progress in Retinal and Eye Research·Marc D de SmetSue Lightman
May 10, 2005·Ophthalmology·Sunil K SrivastavaChi-Chao Chan
Apr 9, 2005·Current Eye Research·Tomoaki IshikawaMasahiko Usui
Apr 25, 2009·Expert Opinion on Investigational Drugs·Fiona LyonSusan Lightman
Mar 15, 2006·Experimental Eye Research·Paul A ConstableN Joan Abbott
Oct 13, 2017·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Kongnara PapangkornWilliam I Higuchi
Dec 24, 2005·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Sarper KarakücükAynur Akin
Feb 24, 2018·ILAR Journal·Brian C Gilger
Jul 4, 2020·International Ophthalmology·Rohan Bir SinghAniruddha Agarwal
Jul 11, 2003·Ocular Immunology and Inflammation·Narciss Okhravi, Susan Lightman
Sep 10, 2020·Drug Design, Development and Therapy·Libei ZhaoDing Lin
Jan 7, 2021·AAPS PharmSciTech·Mayara Rodrigues Brandão De PaivaArmando Silva-Cunha
Jul 30, 2019·International Journal of Pharmaceutics·Aws AlshamsanAfsaneh Lavasanifar
Jun 5, 2004·Progress in Retinal and Eye Research·Tsutomu YasukawaYoshihito Honda

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Related Papers

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Tsutomu YasukawaYuichiro Ogura
Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
M V de Rojas SilvaC Capeans Tomé
© 2021 Meta ULC. All rights reserved