Intravitreal triamcinolone versus laser photocoagulation for persistent diabetic macular oedema

The British Journal of Ophthalmology
Z K OckrimP Hykin

Abstract

To determine if repeated intravitreal triamcinolone improves best corrected visual acuity at 1 year compared with conventional laser therapy for persistent diabetic macular oedema. 88 eyes with persistent clinically significant macular oedema, after at least one prior laser photocoagulation, were included in this prospective randomised controlled trial. 43 patients were randomised to 4 mg of intravitreal triamcinolone (TA) and 45 to laser photocoagulation. The primary endpoint was the proportion of patients who improved by 15 Early Treatment of Diabetic Retinopathy Study (ETDRS) letters at 12 months in TA versus laser groups. Secondary endpoints were the change in mean best corrected visual acuity, difference in macular thickness and macular volume and adverse event reporting in particular elevated intraocular pressure at 12 months. Improvement in > or =15 ETDRS letters occurred in two of 42 patients in the TA group (4.8%) and in five of 41 (12.2%) patients in the laser group (p = 0.265). At baseline, the mean ETDRS scores at baseline were 54.4 letters in the TA group and 53.0 letters in the laser group. At 12 months, these were 54.5 and 54.6, respectively. Optical coherence tomography showed a reduction in central macular thic...Continue Reading

Citations

May 15, 2012·Current Diabetes Reports·Michael W Stewart
Dec 3, 2008·Expert Opinion on Emerging Drugs·Quresh Mohamed, Tien Y Wong
Apr 18, 2009·Seminars in Ophthalmology·Paolo S SilvaLloyd Paul Aiello
Apr 30, 2010·Ophthalmology·UNKNOWN Diabetic Retinopathy Clinical Research NetworkJennifer K Sun
Oct 1, 2009·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Christopher J RudniskyDavid Katz
May 24, 2013·Ocular Immunology and Inflammation·Masoud SoheilianRoham Soheilian
Apr 1, 2015·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Claudio BucoloCaterina Gagliano
Nov 19, 2020·The Cochrane Database of Systematic Reviews·Thanitsara RittiphairojGianni Virgili

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