Intravitreous bevacizumab injection: an experimental study in New Zealand white rabbits

Archives of Ophthalmology
Rafael T CortezG Paolo Giuliari

Abstract

To determine the effects of intraocular pressure (IOP) and needle diameter on the amount of reflux after intravitreous bevacizumab injection. Prospective randomized interventional study. Twelve New Zealand white rabbits weighing approximately 2.5 to 3.5 kg each were randomized 1:1 to group 1 or group 2. Bevacizumab stained with trypan blue was used for intravitreous injection. To lower the IOP, eyes in group 2 underwent anterior chamber paracentesis before intravitreous injection. Two eyes in each group were injected using 27-, 30-, or 32-gauge needles. If a subconjunctival bleb formed after intravitreous injection, its diameter was measured using a caliper. The median IOP in group 1 was 17.5 mm Hg. Eyes injected using 27-gauge and 30-gauge needles showed stained subconjunctival blebs with median sizes of 3 mm and 1.7 mm, respectively; eyes injected using 32-gauge needles showed no subconjunctival bleb formation. The median IOP in group 2 was 10.3 mm Hg. Eyes injected using 27-gauge needles showed stained subconjunctival blebs with a median size of 0.7 mm, and eyes injected using 30-gauge and 32-gauge needles showed no subconjunctival bleb formation. Decreasing the IOP before intravitreous injection and using a smaller-gauge ne...Continue Reading

Associated Clinical Trials

Citations

Nov 22, 2013·Current Eye Research·Frank L BrodieBrian L VanderBeek
Oct 20, 2012·Clinical & Experimental Ophthalmology·Xavier J Fagan, Salmaan Al-Qureshi
Feb 4, 2014·Expert Review of Clinical Pharmacology·Michael W Stewart
Jul 21, 2015·International Journal of Retina and Vitreous·Rohan Merani, Alex P Hunyor
Jan 22, 2013·Clinical & Experimental Ophthalmology·John B ChristoforidisMichael V Knopp
May 15, 2013·Biomedical Microdevices·Chang Yeol LeeHyungil Jung

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