PMID: 8942877Nov 1, 1996Paper

Intravitreous injections of vascular endothelial growth factor produce retinal ischemia and microangiopathy in an adult primate

Ophthalmology
M TolentinoA P Adamis

Abstract

The purpose of the study is to determine the effect of exogenous vascular endothelial growth factor (VEGF) on the primate retina and its vasculature. Ten eyes of five animals were studied. Physiologically relevant amounts of the 165 amino acid isoform of human recombinant VEGF were injected into the vitreous of six healthy cynomolgus monkey eyes. Inactivated human recombinant VEGF or vehicle was injected into four contralateral control subject eyes. Eyes were assessed by slit-lamp biomicroscopy, tonometry, fundus color photography, fundus fluorescein angiography, light microscopy, and immunostaining with antibodies against proliferating cell nuclear antigen and factor VIII antigen. All six bioactive VEGF-injected eyes developed dilated, tortuous retinal vessels that leaked fluorescein. Eyes receiving multiple injections of VEGF developed progressively dilated and tortuous vessels, venous beading, edema, microaneurysms, intraretinal hemorrhages and capillary closure with ischemia. The severity of the retinopathy correlated with the number of VEGF injections. None of the four control eyes exhibited any abnormal retinal vascular changes. The endothelial cells of retinal blood vessels were proliferating cell nuclear antigen positiv...Continue Reading

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Citations

Sep 1, 2005·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Hidetaka NomaHiromu K Mishima
Oct 6, 2007·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Hamid AhmadiehMohammad-Reza Mohebbi
Feb 4, 2009·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·J Fernando ArevaloUNKNOWN Pan-American Collaborative Retina Study Group (PACORES)
Aug 18, 2010·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Hidetaka NomaSadao Hori
Mar 20, 2012·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Luís A AranaMark S Humayun
Dec 18, 2008·Japanese Journal of Ophthalmology·Sebastian Wolf
May 4, 2011·Japanese Journal of Ophthalmology·Hidetaka NomaSadao Hori
May 11, 2005·Ophthalmology·Lindsay M SmithenRichard F Spaide
Feb 28, 2002·American Journal of Ophthalmology·Michael J TolentinoGerard A Lutty
Nov 20, 2002·Biochemical and Biophysical Research Communications·Shinjiro AmanoMasayoshi Takeuchi
May 15, 2003·Survey of Ophthalmology·Jayakrishna AmbatiAnthony P Adamis
Dec 23, 1998·Survey of Ophthalmology·P LeeA P Adamis
Feb 25, 2003·Progress in Retinal and Eye Research·A N WitmerR O Schlingemann
Mar 7, 2006·Nature Reviews. Drug Discovery·Eugene W M NgAnthony P Adamis
Mar 16, 2013·Nature Reviews. Drug Discovery·Guillaume VaquerBruno Sepodes
Sep 21, 2000·Kidney International. Supplement·L P Aiello, J S Wong
Sep 7, 2007·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Suk H ByeonOh W Kwon
Feb 24, 2009·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Chih-Hsin ChenPei-Chang Wu
Mar 19, 2013·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Chang-Sue YangWen-Ming Hsu
Jan 6, 2004·International Ophthalmology Clinics·John B Christoforidis, Donald J D'Amico
Dec 4, 2004·International Ophthalmology Clinics·Kekul B Shah, Dennis P Han
Feb 4, 2005·Retina·Anthony P Adamis, David T Shima

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