Intravoxel incoherent motion diffusion-weighted imaging analysis of diffusion and microperfusion in grading gliomas and comparison with arterial spin labeling for evaluation of tumor perfusion

Journal of Magnetic Resonance Imaging : JMRI
Nanxi ShenWen-Zhen Zhu

Abstract

To determine the utility of intravoxel incoherent motion (IVIM) imaging in grading gliomas and compare IVIM perfusion metrics with arterial spin labeling (ASL)-derived cerebral blood flow (CBF). Fifty-two patients with pathologically confirmed gliomas underwent IVIM and ASL imaging at 3.0T. IVIM perfusion-related diffusivity (D*), perfusion fraction (f), product of f and D*(f×D*), true diffusivity (D), and apparent diffusion coefficient (ADC) were obtained to distinguish glioma grades. The CBF derived from pseudocontinuous ASL within the solid tumor was compared and correlated with IVIM perfusion metrics for grading of gliomas. Values were also normalized to the contralateral normal-appearing white matter. Receiver-operating characteristic was performed to determine diagnostic efficiency. The reliability was estimated with intraclass coefficient, coefficient of variance, and Bland-Altman plots. IVIM perfusion metrics and CBF were significantly higher in the high-grade than the low-grade gliomas (P < 0.001), ADC and D were significantly lower in the high-grade than the low-grade gliomas (P < 0.001). f×D* differed significantly between grades II through IV (P < 0.05 for all). The other metrics showed significant difference betwee...Continue Reading

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Citations

May 10, 2018·Journal of Magnetic Resonance Imaging : JMRI·Miaomiao ZhangXinming Zhao
Feb 16, 2017·Stroke; a Journal of Cerebral Circulation·C Eleana ZhangRobert J van Oostenbrugge
Feb 13, 2018·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Takuya UrushihataTakayuki Obata
Jan 10, 2019·Journal of Magnetic Resonance Imaging : JMRI·Yang YangGuang-Bin Cui
Mar 25, 2018·Journal of Magnetic Resonance Imaging : JMRI·Qiang TianGuang-Bin Cui
Mar 17, 2019·European Radiology·Yi WeiBin Song
Sep 16, 2020·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Gao MaFei Yun Wu
Aug 30, 2020·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Yujie LiYuqing Shang
May 11, 2017·Clinical Neuroradiology·Cornelia BrendleUwe Klose
Jan 9, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Pejman Jabehdar MaralaniArjun Sahgal
Mar 12, 2021·Frontiers in Human Neuroscience·Yen-Peng LiaoHidenao Fukuyama
Apr 28, 2021·Magnetic Resonance Imaging Clinics of North America·Christian Federau

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