Intravoxel Incoherent Motion Imaging in Differentiation Borderline From Malignant Ovarian Epithelial Tumors: Correlation With Histological Cell Proliferation and Vessel Characteristics.

Journal of Magnetic Resonance Imaging : JMRI
Xiao-Li SongJinliang Niu

Abstract

The differentiation of borderline from malignant ovarian epithelial tumors (OETs) is difficult based on morphologic characteristics. Diffusion and perfusion information from intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) might be useful for this distinction. To investigate the potential of IVIM-DWI in discriminating borderline from malignant OETs by correlating with cell proliferation and microvessel density (MVD). Prospective. Sixty-six patients with OETs (22 borderline, BOETs; 44 malignant, MOETs) underwent IVIM-DWI before surgery. 3.0T IVIM-DWI sequence with 12 b-values (0-1000 sec/mm2 ). Apparent diffusion coefficient (ADC) and IVIM-DWI parameters (diffusion coefficient [D], microvascular volume fraction [f], and pseudodiffusion coefficient [D*]) were measured. Cell proliferation and MVD was determined by immunohistochemical staining of Ki-67 and CD-31, respectively. Mann-Whitney U-test; two-sample t-test; intraclass correlation coefficient; Bland-Altman analysis; receiver operating characteristics (ROC) curves; and Spearman correlation. ADC and D in BOETs was significantly higher than those in MOETs (P < 0.001), while f in BOETs was significantly lower than those in MOETs (P < 0.001). No significant d...Continue Reading

References

Sep 1, 1992·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·D Le Bihan, R Turner
Sep 30, 1993·International Journal of Cancer. Journal International Du Cancer·M ToiT Tominaga
Aug 15, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M AnttilaK Syrjänen
Feb 13, 2001·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·D TimmermanUNKNOWN International Ovarian Tumor Analysis (IOTA) Group
Nov 29, 2002·Molecular Pathology : MP·E S Bamberger, C W Perrett
May 7, 2003·Cancer·Vivien W ChenCatherine N Correa
Jun 27, 2008·Journal of Magnetic Resonance Imaging : JMRI·Isabelle Thomassin-NaggaraMarc Bazot
Oct 13, 2009·European Journal of Internal Medicine·Nektaria MakriliaKostas Syrigos
May 10, 2011·Magnetic Resonance Imaging·Andreas LemkeFrederik B Laun
Oct 2, 2012·The Oncologist·Daniela FischerovaDavid Cibula
Jun 26, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Hye-Jeong LeeByoung Wook Choi
Apr 29, 2014·Lancet·Gordon C JaysonJonathan A Ledermann
Jan 22, 2015·European Radiology·Jessica M WinfieldDavid J Collins
Jun 18, 2015·The British Journal of Radiology·S M MansourY El-Faissal
Jan 16, 2017·Journal of Ovarian Research·Hai-Ming LiShu-Hui Zhao
Apr 4, 2017·Journal of Magnetic Resonance Imaging : JMRI·Isabelle Thomassin-NaggaraCharles-André Cuenod
Apr 19, 2017·Journal of Magnetic Resonance Imaging : JMRI·Haijun WuFangping Xu
Dec 28, 2017·European Journal of Radiology·Yong Ai LiShu Hui Zhao
May 8, 2018·Journal of Magnetic Resonance Imaging : JMRI·Shaocheng ZhuBin Song
Feb 4, 2019·Anticancer Research·Lene RaskEstrid V S Høgdall

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