Intravoxel incoherent motion magnetic resonance imaging of the normal-appearing parotid glands in patients with differentiated thyroid cancer after radioiodine therapy

Acta Radiologica
Jie ShenFei-Yun Wu

Abstract

Background Radiation damage to the salivary gland is a common complication of radioiodine therapy (RIT) in the patients with differentiated thyroid cancer (DTC). Purpose To investigate the feasibility of using intravoxel incoherent motion (IVIM) magnetic resonance imaging (MRI) to detect radiation-induced changes of normal-appearing parotid glands in the patients after RIT for DTC. Material and Methods We prospectively enrolled 20 patients with RIT-induced sialoadenitis and 20 healthy control (HC) participants. The patients were divided into intermediate and late groups, and a questionnaire was used to assess the related symptoms. IVIM MRI was scanned using nine b-values (0, 50, 100, 150, 200, 400, 600, 800, and 1000 s/mm2). Quantitative parameters (pseudodiffusion coefficient, D*; perfusion fraction, f; tissue diffusivity, D) were obtained using a biexponential model and compared among different groups using one-way analysis of variance (ANOVA) test. Correlations between significant parameters and symptom score were assessed using Spearman's correlation analysis. Results The f and D value differed significantly (f, P = 0.016; D, P = 0.006) among different groups. Post hoc analysis showed that f and D value of intermediate grou...Continue Reading

References

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Apr 24, 2013·Thyroid : Official Journal of the American Thyroid Association·Jeong-Seok ChoiYoung-Mo Kim
Apr 5, 2014·Journal of Magnetic Resonance Imaging : JMRI·Simona MarziAntonello Vidiri
Mar 27, 2015·Thyroid : Official Journal of the American Thyroid Association·Jeong-Seok ChoiYoung-Mo Kim
Apr 11, 2015·Thyroid : Official Journal of the American Thyroid Association·Mihir K BhayaniStephen Y Lai
Sep 3, 2016·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Xiao Quan XuJeong Hyun Lee

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Citations

Sep 16, 2020·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Gao MaFei Yun Wu

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Software Mentioned

MedCalc
SPSS
MathWorks
Matlab

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