Intravoxel incoherent motion MRI as a biomarker of sorafenib treatment for advanced hepatocellular carcinoma: a pilot study

Cancer Imaging : the Official Publication of the International Cancer Imaging Society
Natsuhiko ShirotaKoichi Tokuuye

Abstract

To evaluate the association between the therapeutic outcomes of sorafenib for advanced hepatocellular carcinoma (HCC) and the parameters of intravoxel incoherent motion (IVIM). Nine patients were evaluated prospectively. All patients were Child-Pugh score A. The mean dimension of the lesion was 32 mm (range: 15-74 mm). MR images were obtained using a 1.5-Tesla superconductive MRI system. Diffusion-weighted imaging was performed under breath-holding using b-values of 0, 50, 100, 150, 200, 400, and 800 s/mm(2). The following IVIM parameters were calculated: apparent diffusion coefficient, true diffusion coefficient (DC), pseudo-diffusion coefficient, and perfusion fraction. MRI was performed before treatment and at 1, 2, and 4 weeks after beginning treatment. Tumor response at 4 weeks was assessed by CT or MRI using modified RECIST. IVIM parameters of the treatment responders and non-responders were compared. The DC of responders at baseline was significantly higher than that of the non-responders. The sensitivity and specificity, when a DC of 0.8 (10(-3) mm(2)/s) or higher was considered to be a responder, were 100 % and 67 %, respectively. No significant differences were found in the other parameters between the responders and ...Continue Reading

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Citations

Dec 9, 2016·World Journal of Radiology·Kazuhiro SaitoTaiyo L Harada
Dec 14, 2019·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Qian LiangJie Tian
Jun 17, 2020·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Mami Iima
Mar 17, 2019·European Radiology·Yi WeiBin Song
Oct 11, 2017·World Journal of Hepatology·Anuradha Shenoy-BhangleAvinash Kambadakone
Sep 3, 2020·World Journal of Clinical Cases·Yun-Yun TaoXiao-Ming Zhang
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Nov 13, 2020·Scientific Reports·Chih-Chieh ChiangHsin-Hon Lin
Jul 3, 2021·Journal of Clinical Medicine·Liberatore TramontanoValentina Brancato
Oct 14, 2021·Scientific Reports·Mariana Inri de CarvalhoGiédre Berretin-Felix

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