Intricacies of BMP receptor assembly

Cytokine & Growth Factor Reviews
J NickelThomas D Mueller

Abstract

The TGF-beta superfamily exhibits a feature making it distinct from many other growth factor families in that the inadequate number of ligands and receptors premises a high degree of promiscuity in ligand-receptor interaction. This highlights the importance of even small differences in affinities and specificities between different binding partners to maintain the broad spectrum of their well defined biological functions. Despite the promiscuous interactions recent data reveal differences in receptor recruitment, architectures of these assemblies and specific modulation by a multitude of extracellular as well as membrane-associated factors. These modulatory mechanisms might possibly add specificity towards defined biological functions despite the overlapping usage of receptors by various ligands.

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Citations

Aug 10, 2010·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Stefan HarthThomas Dieter Mueller
May 6, 2011·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Joachim NickelThomas D Mueller
Mar 22, 2013·PloS One·Thaleia KouskouraDaniel Graf
Oct 25, 2013·PloS One·Hua ShenStavros Thomopoulos
Sep 28, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Juliane E FiebigThomas D Mueller
Feb 2, 2012·FEBS Letters·Marcelo EhrlichYoav I Henis
Jun 20, 2012·FEBS Letters·Thomas D Mueller, Joachim Nickel
Jul 3, 2013·Journal of Colloid and Interface Science·Dong ZhengEn-Tang Kang
Jan 3, 2013·Trends in Genetics : TIG·Karen BeetsAn Zwijsen
Jan 10, 2012·The International Journal of Biochemistry & Cell Biology·Daniel HorbeltPetra Knaus
Aug 10, 2010·The International Journal of Biochemistry & Cell Biology·J H BoergermannP Knaus
Aug 3, 2010·Cytokine & Growth Factor Reviews·Jonathan W Lowery, Mark P de Caestecker
Apr 13, 2010·Trends in Endocrinology and Metabolism : TEM·Melissa L Brown, Alan L Schneyer
Jan 9, 2013·Advanced Healthcare Materials·Pujiang ShiJames C H Goh
Dec 17, 2011·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Viet Q Le, Kristi A Wharton
Mar 23, 2011·The EMBO Journal·Tao HuangAndrew P Hinck
Jun 1, 2015·The Journal of Surgical Research·Günter FinkenzellerSandra Strassburg
Jun 4, 2015·Nature Structural & Molecular Biology·Thomas D Mueller
Jan 17, 2015·Trends in Cell Biology·Derek P BrazilFinian Martin
Apr 11, 2012·Microvascular Research·G FinkenzellerG B Stark
Oct 11, 2016·Chemical Communications : Chem Comm·Manuel Salmerón-Sánchez, Matthew J Dalby
Mar 28, 2013·International Journal of Molecular Sciences·Andrea ConidiDanny Huylebroeck

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